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CHEBI:71219 - pazopanib

ChEBI IDCHEBI:71219
ChEBI Namepazopanib
Stars
DefinitionA pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Last Modified3 February 2020
SubmitterSteve
DownloadsMolfile
FormulaC21H23N7O2S
Net Charge0
Average Mass437.529
Monoisotopic Mass437.16339
SMILESCc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O
InChIInChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKeyCUIHSIWYWATEQL-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
tyrosine kinase inhibitor  Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis modulating agent  An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
ChEBI Ontology
Outgoing Relation(s)
pazopanib (CHEBI:71219) has role angiogenesis modulating agent (CHEBI:50926)
pazopanib (CHEBI:71219) has role antineoplastic agent (CHEBI:35610)
pazopanib (CHEBI:71219) has role tyrosine kinase inhibitor (CHEBI:38637)
pazopanib (CHEBI:71219) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
pazopanib (CHEBI:71219) is a aminopyrimidine (CHEBI:38338)
pazopanib (CHEBI:71219) is a indazoles (CHEBI:38769)
pazopanib (CHEBI:71219) is a sulfonamide (CHEBI:35358)
pazopanib (CHEBI:71219) is conjugate base of pazopanib(1+) (CHEBI:71218)
Incoming Relation(s)
pazopanib(1+) (CHEBI:71218) is conjugate acid of pazopanib (CHEBI:71219)
IUPAC Name 
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
INNs  Source
pazopanibumWHO MedNet
pazopanibWHO MedNet
pazopanibWHO MedNet
pazopanibWHO MedNet
Synonyms  Source
GW786034ChemIDplus
GW 78603ChemIDplus
Manual XrefsDatabases
WO2007064753Patent
US2008293691Patent
WO2006020564Patent
WO2007143483Patent
WO2011058179Patent
WO2011069053Patent
WO2012106302Patent
WO2011150044Patent
PazopanibWikipedia
LSM-1114LINCS
4118DrugCentral
Registry NumbersSources
Reaxys:11646488Reaxys
CAS:444731-52-6ChemIDplus
Citations