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CHEBI:71217 - pazopanib hydrochloride

ChEBI IDCHEBI:71217
ChEBI Namepazopanib hydrochloride
Stars
DefinitionA hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer.
Last Modified3 February 2020
SubmitterSteve
DownloadsMolfile
FormulaC21H23N7O2S.HCl
Net Charge0
Average Mass473.990
Monoisotopic Mass473.14007
SMILESCc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O.Cl
InChIInChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
InChIKeyMQHIQUBXFFAOMK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
tyrosine kinase inhibitor  Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis modulating agent  An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
ChEBI Ontology
Outgoing Relation(s)
pazopanib hydrochloride (CHEBI:71217) has part pazopanib(1+) (CHEBI:71218)
pazopanib hydrochloride (CHEBI:71217) has role angiogenesis modulating agent (CHEBI:50926)
pazopanib hydrochloride (CHEBI:71217) has role antineoplastic agent (CHEBI:35610)
pazopanib hydrochloride (CHEBI:71217) has role tyrosine kinase inhibitor (CHEBI:38637)
pazopanib hydrochloride (CHEBI:71217) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
pazopanib hydrochloride (CHEBI:71217) is a hydrochloride (CHEBI:36807)
IUPAC Name 
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide hydrochloride
Synonyms  Source
pazopanib HClChEBI
5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochlorideChemIDplus
pazopanib monohydrochlorideChEBI
GW786034BChemIDplus
Brand Name  Source
VotrientKEGG DRUG
Manual XrefsDatabases
D05380KEGG DRUG
WO2009062658Patent
WO2007064753Patent
US2008293691Patent
WO2006020564Patent
WO2007143483Patent
WO2005105094Patent
WO2011150044Patent
Pazopanib_hydrochlorideWikipedia
WO2011069053Patent
Registry NumbersSources
Reaxys:11572612Reaxys
CAS:635702-64-6KEGG DRUG
CAS:635702-64-6ChemIDplus
Citations