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CHEBI:71028 - carglumic acid

ChEBI IDCHEBI:71028
ChEBI Namecarglumic acid
Stars
DefinitionA urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Last Modified20 March 2024
SubmitterSteve
DownloadsMolfile
FormulaC6H10N2O5
Net Charge0
Average Mass190.155
Monoisotopic Mass190.05897
SMILESNC(=O)N[C@@H](CCC(=O)O)C(=O)O
InChIInChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
InChIKeyLCQLHJZYVOQKHU-VKHMYHEASA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
carbamylphosphate synthetase I activator  Any compound that binds and activates the enzyme carbamylphosphate synthetase I.
Application:
orphan drug  Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
ChEBI Ontology
Outgoing Relation(s)
carglumic acid (CHEBI:71028) has role carbamylphosphate synthetase I activator (CHEBI:71033)
carglumic acid (CHEBI:71028) has role orphan drug (CHEBI:71031)
carglumic acid (CHEBI:71028) is a N-acyl-L-glutamic acid (CHEBI:21650)
carglumic acid (CHEBI:71028) is a ureas (CHEBI:47857)
carglumic acid (CHEBI:71028) is conjugate acid of N-carbamoyl-L-glutamate(2−) (CHEBI:229697)
Incoming Relation(s)
N-carbamoyl-L-glutamate(2−) (CHEBI:229697) is conjugate base of carglumic acid (CHEBI:71028)
IUPAC Name 
N-carbamoyl-L-glutamic acid
INNs  Source
carglumic acidKEGG DRUG
ácido carglúmicoWHO MedNet
acide carglumiqueWHO MedNet
acidum carglumicumWHO MedNet
Synonyms  Source
Carbamino-L-glutamic acidChemIDplus
L-N-Carbamoylglutamic acidChemIDplus
Ureidoglutaric acidChemIDplus
Carbamylglutamic acidChemIDplus
(2S)-2-(carbamoylamino)pentanedioic acidHMDB
Brand Name  Source
CarbagluKEGG DRUG
Manual XrefsDatabases
D07130KEGG DRUG
C05829KEGG COMPOUND
DB06775DrugBank
HMDB0015673HMDB
N-CARBAMYL-L-GLUTAMATEMetaCyc
Carglumic_acidWikipedia
3068DrugCentral
Registry NumbersSources
Reaxys:1727929Reaxys
CAS:1188-38-1KEGG DRUG
CAS:1188-38-1ChemIDplus
CAS:1188-38-1KEGG COMPOUND
Citations