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CHEBI:71019 - omacetaxine mepesuccinate

Default Structure
ChEBI IDCHEBI:71019
ChEBI Nameomacetaxine mepesuccinate
Stars
DefinitionA cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Last Modified23 April 2020
SubmitterSteve
DownloadsMolfile
FormulaC29H39NO9
Net Charge0
Average Mass545.629
Monoisotopic Mass545.26248
SMILES[H][C@]12c3cc4c(cc3CCN3CCC[C@@]31C=C(OC)[C@H]2OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)OCO4
InChIInChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKeyHYFHYPWGAURHIV-JFIAXGOJSA-N
Wikipedia
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
protein synthesis inhibitor  A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
metabolite  Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
omacetaxine mepesuccinate (CHEBI:71019) has functional parent cephalotaxine (CHEBI:3540)
omacetaxine mepesuccinate (CHEBI:71019) has role anticoronaviral agent (CHEBI:149553)
omacetaxine mepesuccinate (CHEBI:71019) has role antineoplastic agent (CHEBI:35610)
omacetaxine mepesuccinate (CHEBI:71019) has role apoptosis inducer (CHEBI:68495)
omacetaxine mepesuccinate (CHEBI:71019) has role protein synthesis inhibitor (CHEBI:48001)
omacetaxine mepesuccinate (CHEBI:71019) is a alkaloid ester (CHEBI:38481)
omacetaxine mepesuccinate (CHEBI:71019) is a enol ether (CHEBI:47985)
omacetaxine mepesuccinate (CHEBI:71019) is a organic heteropentacyclic compound (CHEBI:38164)
omacetaxine mepesuccinate (CHEBI:71019) is a tertiary alcohol (CHEBI:26878)
INNs  Source
mépésuccinate d'omacétaxineWHO MedNet
mepesuccinato de omacetaxinaWHO MedNet
omacetaxine mepesuccinateWHO MedNet
omacetaxini mepesuccinasWHO MedNet
Synonyms  Source
(2'R,3S,4S,5R)-(−)-homoharringtonineChEBI
CGX-635ChemIDplus
(−)-homoharringtonineChEBI
HomoharringtonineKEGG DRUG
Brand Name  Source
SynriboChemIDplus
Manual XrefsDatabases
4677DrugCentral
D08956KEGG DRUG
HMTPDBeChem
LSM-3716LINCS
Omacetaxine_mepesuccinateWikipedia
US2010240887Patent
WO2007089878Patent
Registry NumbersSources
Reaxys:5687925Reaxys
CAS:26833-87-4KEGG DRUG
CAS:26833-87-4ChemIDplus
Citations