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CHEBI:71019 - omacetaxine mepesuccinate

Default Structure
ChEBI IDCHEBI:71019
ChEBI Nameomacetaxine mepesuccinate
Stars
DefinitionA cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Last Modified23 April 2020
SubmitterSteve
DownloadsMolfile
FormulaC29H39NO9
Net Charge0
Average Mass545.629
Monoisotopic Mass545.26248
SMILES[H][C@]12c3cc4c(cc3CCN3CCC[C@@]31C=C(OC)[C@H]2OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)OCO4
InChIInChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKeyHYFHYPWGAURHIV-JFIAXGOJSA-N
Wikipedia
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
protein synthesis inhibitor  A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
metabolite  Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
omacetaxine mepesuccinate (CHEBI:71019) has functional parent cephalotaxine (CHEBI:3540)
omacetaxine mepesuccinate (CHEBI:71019) has role anticoronaviral agent (CHEBI:149553)
omacetaxine mepesuccinate (CHEBI:71019) has role antineoplastic agent (CHEBI:35610)
omacetaxine mepesuccinate (CHEBI:71019) has role apoptosis inducer (CHEBI:68495)
omacetaxine mepesuccinate (CHEBI:71019) has role protein synthesis inhibitor (CHEBI:48001)
omacetaxine mepesuccinate (CHEBI:71019) is a alkaloid ester (CHEBI:38481)
omacetaxine mepesuccinate (CHEBI:71019) is a enol ether (CHEBI:47985)
omacetaxine mepesuccinate (CHEBI:71019) is a organic heteropentacyclic compound (CHEBI:38164)
omacetaxine mepesuccinate (CHEBI:71019) is a tertiary alcohol (CHEBI:26878)
INNs  Source
mépésuccinate d'omacétaxineWHO MedNet
mepesuccinato de omacetaxinaWHO MedNet
omacetaxine mepesuccinateWHO MedNet
omacetaxini mepesuccinasWHO MedNet
Synonyms  Source
(2'R,3S,4S,5R)-(−)-homoharringtonineChEBI
CGX-635ChemIDplus
(−)-homoharringtonineChEBI
HomoharringtonineKEGG DRUG
Brand Name  Source
SynriboChemIDplus
Manual XrefsDatabases
4677DrugCentral
D08956KEGG DRUG
HMTPDBeChem
LSM-3716LINCS
Omacetaxine_mepesuccinateWikipedia
US2010240887Patent
WO2007089878Patent
Registry NumbersSources
Reaxys:5687925Reaxys
CAS:26833-87-4KEGG DRUG
CAS:26833-87-4ChemIDplus
Citations