conivaptan (CHEBI:681850)

CHEBI:681850 - conivaptan

ChEBI ID	CHEBI:681850
ChEBI Name	conivaptan
Stars
Definition	The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V_1a and V₂. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
Last Modified	20 February 2023
Downloads	Molfile

Formula	C32H26N4O2
Net Charge	0
Average Mass	498.586
Monoisotopic Mass	498.20558
SMILES	Cc1nc2c(n1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2
InChI	InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
InChIKey	IKENVDNFQMCRTR-UHFFFAOYSA-N

Wikipedia

Roles Classification

vasopressin receptor antagonist Any drug which blocks vasopressin receptors.

hepatoprotective agent Any compound that is able to prevent damage to the liver.

neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

vasopressin receptor antagonist Any drug which blocks vasopressin receptors.

aquaretic A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss).

cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.

ChEBI Ontology

Outgoing Relation(s)
	conivaptan (CHEBI:681850) has role aquaretic (CHEBI:194423)
	conivaptan (CHEBI:681850) has role cardiovascular drug (CHEBI:35554)
	conivaptan (CHEBI:681850) has role hepatoprotective agent (CHEBI:62868)
	conivaptan (CHEBI:681850) has role neuroprotective agent (CHEBI:63726)
	conivaptan (CHEBI:681850) has role vasopressin receptor antagonist (CHEBI:59680)
	conivaptan (CHEBI:681850) is a benzazepine (CHEBI:35676)
Incoming Relation(s)
Incoming Relation(s)	conivaptan hydrochloride (CHEBI:31430) has part conivaptan (CHEBI:681850)

IUPAC Name
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide

INN	Source
conivaptan	ChemIDplus

Synonyms	Source
4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide	ChemIDplus
Conivaptan	ChEMBL

Citations