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CHEBI:681850 - conivaptan

ChEBI IDCHEBI:681850
ChEBI Nameconivaptan
Stars
DefinitionThe amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
Last Modified20 February 2023
DownloadsMolfile
FormulaC32H26N4O2
Net Charge0
Average Mass498.586
Monoisotopic Mass498.20558
SMILESCc1nc2c(n1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2
InChIInChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
InChIKeyIKENVDNFQMCRTR-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
vasopressin receptor antagonist  Any drug which blocks vasopressin receptors.
Applications:
aquaretic  A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss).
vasopressin receptor antagonist  Any drug which blocks vasopressin receptors.
ChEBI Ontology
Outgoing Relation(s)
conivaptan (CHEBI:681850) has role aquaretic (CHEBI:194423)
conivaptan (CHEBI:681850) has role vasopressin receptor antagonist (CHEBI:59680)
conivaptan (CHEBI:681850) is a benzazepine (CHEBI:35676)
Incoming Relation(s)
conivaptan hydrochloride (CHEBI:31430) has part conivaptan (CHEBI:681850)
IUPAC Name 
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
INN  Source
conivaptanChemIDplus
Synonyms  Source
ConivaptanChEMBL
4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilideChemIDplus
Manual XrefsDatabases
DB00872DrugBank
D07748KEGG DRUG
ConivaptanWikipedia
732DrugCentral
Registry NumbersSources
Beilstein:8658375Beilstein
CAS:210101-16-9ChemIDplus
CAS:210101-16-9KEGG DRUG
Citations