CHEBI:6741 - meloxicam

ChEBI IDCHEBI:6741
ChEBI Namemeloxicam
Stars
DefinitionA benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Last Modified19 June 2017
DownloadsMolfile
FormulaC14H13N3O4S2
Net Charge0
Average Mass351.409
Monoisotopic Mass351.03475
SMILESCc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1
InChIInChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
InChIKeyZRVUJXDFFKFLMG-UHFFFAOYSA-N
Roles Classification
Biological Roles:
antitubercular agent  A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antitubercular agent  A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
antirheumatic drug  A drug used to treat rheumatoid arthritis.
ChEBI Ontology
Outgoing Relation(s)
meloxicam (CHEBI:6741) has role analgesic (CHEBI:35480)
meloxicam (CHEBI:6741) has role anti-inflammatory agent (CHEBI:67079)
meloxicam (CHEBI:6741) has role antineoplastic agent (CHEBI:35610)
meloxicam (CHEBI:6741) has role antirheumatic drug (CHEBI:35842)
meloxicam (CHEBI:6741) has role antitubercular agent (CHEBI:33231)
meloxicam (CHEBI:6741) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
meloxicam (CHEBI:6741) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
meloxicam (CHEBI:6741) is a 1,3-thiazoles (CHEBI:38418)
meloxicam (CHEBI:6741) is a benzothiazine (CHEBI:46899)
meloxicam (CHEBI:6741) is a monocarboxylic acid amide (CHEBI:29347)
IUPAC Name 
4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
INNs  Source
meloxicamWHO MedNet
meloxicamWHO MedNet
méloxicamWHO MedNet
meloxicamumWHO MedNet
Synonyms  Source
ActicamChEMBL
ContaceraChEMBL
CoxicamChEMBL
EmdocamChEMBL
FlexicamChEMBL
InflacamChEMBL
Brand Names  Source
AnjesoChEMBL
LoxitabChEMBL
Meloxicam component of zelerisChEMBL
Meloxicam component of zynrelefChEMBL
MobicKEGG DRUG
NovaquinChEMBL
Manual XrefsDatabases
1676DrugCentral
1751VSDB
C08169KEGG COMPOUND
D00969KEGG DRUG
DB00814DrugBank
DE2756113Patent
HMDB0014952HMDB
US4233299Patent
Registry NumbersSources
Reaxys:5886369Reaxys
CAS:71125-38-7KEGG COMPOUND
Citations