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CHEBI:67169 - cortistatins
| ChEBI ID | CHEBI:67169 |
| ChEBI Name | cortistatins |
| Stars | |
| Definition | Any member of a class of steroidal alkaloids obtained from the marine sponge Corticium simplex, with a basic skeleton that is (5R,8β)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs). |
| Last Modified | 21 August 2012 |
| Submitter | Gareth Owen |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Role: | metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| Application: | angiogenesis modulating agent An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| cortistatins (CHEBI:67169) has role angiogenesis modulating agent (CHEBI:50926) |
| cortistatins (CHEBI:67169) is a polycyclic ether (CHEBI:36468) |
| cortistatins (CHEBI:67169) is a steroid alkaloid (CHEBI:26767) |
| cortistatins (CHEBI:67169) is a tertiary amino compound (CHEBI:50996) |
| Incoming Relation(s) |
| cortistatin A (CHEBI:67171) is a cortistatins (CHEBI:67169) |
| cortistatin B (CHEBI:67173) is a cortistatins (CHEBI:67169) |
| cortistatin C (CHEBI:67174) is a cortistatins (CHEBI:67169) |
| cortistatin D (CHEBI:67175) is a cortistatins (CHEBI:67169) |
| cortistatin E (CHEBI:67179) is a cortistatins (CHEBI:67169) |
| Manual Xrefs | Databases |
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| Cortistatins | Wikipedia |
| Citations |
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