maytansine (CHEBI:6701)

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:6701 - maytansine

ChEBI ID	CHEBI:6701
ChEBI Name	maytansine
Stars
Definition	An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.
Last Modified	22 August 2014
Downloads	Molfile

Formula	C34H46ClN3O10
Net Charge	0
Average Mass	692.206
Monoisotopic Mass	691.28717
SMILES	[H][C@@]12O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N(C)c1cc(cc(OC)c1Cl)C/C(C)=C/C=C/[C@@H](OC)[C@@]1(O)C[C@]([H])(OC(=O)N1)[C@H]2C
InChI	InChI=1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1
InChIKey	WKPWGQKGSOKKOO-RSFHAFMBSA-N

Wikipedia

Roles Classification

Biological Roles:

antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.

antimitotic Any compound that inhibits cell division (mitosis).

tubulin modulator Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.

plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.

Application:

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology

Outgoing Relation(s)
	maytansine (CHEBI:6701) has role antimicrobial agent (CHEBI:33281)
	maytansine (CHEBI:6701) has role antimitotic (CHEBI:64911)
	maytansine (CHEBI:6701) has role antineoplastic agent (CHEBI:35610)
	maytansine (CHEBI:6701) has role plant metabolite (CHEBI:76924)
	maytansine (CHEBI:6701) has role tubulin modulator (CHEBI:60832)
	maytansine (CHEBI:6701) is a carbamate ester (CHEBI:23003)
	maytansine (CHEBI:6701) is a epoxide (CHEBI:32955)
	maytansine (CHEBI:6701) is a maytansinoid (CHEBI:82760)
	maytansine (CHEBI:6701) is a organic heterotetracyclic compound (CHEBI:38163)
	maytansine (CHEBI:6701) is a organochlorine compound (CHEBI:36683)
	maytansine (CHEBI:6701) is a α-amino acid ester (CHEBI:46874)
Incoming Relation(s)
Incoming Relation(s)	mertansine (CHEBI:82755) has functional parent maytansine (CHEBI:6701)

IUPAC Name
(4β,5β,11E,13E)-maytansine

INNs	Source
maitansina	WHO MedNet
maitansine	WHO MedNet
maitansine	WHO MedNet
maitansinum	WHO MedNet

Synonyms	Source
Maytansine	KEGG COMPOUND
NSC 153858	ChemIDplus
NSC-153858	ChemIDplus

Manual Xrefs	Databases
C00002351	KNApSAcK
C10606	KEGG COMPOUND
D04864	KEGG DRUG
LMPK04000017	LIPID MAPS
Maytansine	Wikipedia

Registry Numbers	Sources
Reaxys:5417399	Reaxys
CAS:35846-53-8	KEGG COMPOUND
CAS:35846-53-8	ChemIDplus

Citations