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CHEBI:6541 - losartan
| Formula | C22H23ClN6O |
| Net Charge | 0 |
| Average Mass | 422.920 |
| Monoisotopic Mass | 422.16219 |
| SMILES | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnnn2)cc1 |
| InChI | InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
| InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antiviral agent A substance that destroys or inhibits replication of viruses. endothelin receptor antagonist A hormone antagonist that blocks endothelin receptors. |
| Applications: | anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. hypoglycemic agent A drug which lowers the blood glucose level. angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors. vulnerary A drug used in treating and healing of wounds. anti-inflammatory agent Any compound that has anti-inflammatory effects. antifibrotic agent Any agent which acts to reduce fibrosis. renoprotective agent Any compound that is able to prevent damage to the kidneys. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. endothelin receptor antagonist A hormone antagonist that blocks endothelin receptors. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| losartan (CHEBI:6541) has role angiotensin receptor antagonist (CHEBI:61016) |
| losartan (CHEBI:6541) has role anti-anaemic agent (CHEBI:75835) |
| losartan (CHEBI:6541) has role anti-arrhythmia drug (CHEBI:38070) |
| losartan (CHEBI:6541) has role anti-HIV agent (CHEBI:64946) |
| losartan (CHEBI:6541) has role anti-inflammatory agent (CHEBI:67079) |
| losartan (CHEBI:6541) has role antidepressant (CHEBI:35469) |
| losartan (CHEBI:6541) has role antifibrotic agent (CHEBI:233423) |
| losartan (CHEBI:6541) has role antihypertensive agent (CHEBI:35674) |
| losartan (CHEBI:6541) has role antineoplastic agent (CHEBI:35610) |
| losartan (CHEBI:6541) has role antiviral agent (CHEBI:22587) |
| losartan (CHEBI:6541) has role cardiovascular drug (CHEBI:35554) |
| losartan (CHEBI:6541) has role endothelin receptor antagonist (CHEBI:51451) |
| losartan (CHEBI:6541) has role geroprotector (CHEBI:176497) |
| losartan (CHEBI:6541) has role hypoglycemic agent (CHEBI:35526) |
| losartan (CHEBI:6541) has role nephroprotective agent (CHEBI:76595) |
| losartan (CHEBI:6541) has role renoprotective agent (CHEBI:231911) |
| losartan (CHEBI:6541) has role vulnerary (CHEBI:73336) |
| losartan (CHEBI:6541) is a biphenylyltetrazole (CHEBI:48420) |
| losartan (CHEBI:6541) is a imidazoles (CHEBI:24780) |
| losartan (CHEBI:6541) is conjugate acid of losartan(1−) (CHEBI:149504) |
| Incoming Relation(s) |
| losartan carboxylic acid (CHEBI:74125) has functional parent losartan (CHEBI:6541) |
| losartan(1−) (CHEBI:149504) is conjugate base of losartan (CHEBI:6541) |
| IUPAC Name |
|---|
| (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol |
| INN | Source |
|---|---|
| losartan | ChemIDplus |
| Synonyms | Source |
|---|---|
| (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol | IUPAC |
| 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole | IUPHAR |
| Angizaar | ChEMBL |
| Dup-89 | ChEMBL |
| E-3174 | ChEMBL |
| Exp-3174 | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4770867 | Reaxys |
| CAS:114798-26-4 | KEGG COMPOUND |
| CAS:114798-26-4 | ChemIDplus |
| Citations |
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