EMBL-EBI | Chemical Biology Resources | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:6538 - loratadine
| Formula | C22H23ClN2O2 |
| Net Charge | 0 |
| Average Mass | 382.891 |
| Monoisotopic Mass | 382.14481 |
| SMILES | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 |
| InChI | InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 |
| InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antiviral agent A substance that destroys or inhibits replication of viruses. |
| Applications: | H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antirheumatic drug A drug used to treat rheumatoid arthritis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. anti-asthmatic agent Any compound that has anti-asthmatic effects. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. anti-allergic agent A drug used to treat allergic reactions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342) |
| loratadine (CHEBI:6538) has role analgesic (CHEBI:35480) |
| loratadine (CHEBI:6538) has role anti-allergic agent (CHEBI:50857) |
| loratadine (CHEBI:6538) has role anti-asthmatic agent (CHEBI:65023) |
| loratadine (CHEBI:6538) has role antineoplastic agent (CHEBI:35610) |
| loratadine (CHEBI:6538) has role antirheumatic drug (CHEBI:35842) |
| loratadine (CHEBI:6538) has role antiviral agent (CHEBI:22587) |
| loratadine (CHEBI:6538) has role cholinergic antagonist (CHEBI:48873) |
| loratadine (CHEBI:6538) has role dermatologic drug (CHEBI:50177) |
| loratadine (CHEBI:6538) has role geroprotector (CHEBI:176497) |
| loratadine (CHEBI:6538) has role H1-receptor antagonist (CHEBI:37955) |
| loratadine (CHEBI:6538) has role immunosuppressive agent (CHEBI:35705) |
| loratadine (CHEBI:6538) is a N-acylpiperidine (CHEBI:48591) |
| loratadine (CHEBI:6538) is a benzocycloheptapyridine (CHEBI:48593) |
| loratadine (CHEBI:6538) is a ethyl ester (CHEBI:23990) |
| loratadine (CHEBI:6538) is a organochlorine compound (CHEBI:36683) |
| loratadine (CHEBI:6538) is a tertiary carboxamide (CHEBI:140326) |
| IUPAC Name |
|---|
| ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate |
| INNs | Source |
|---|---|
| loratadina | WHO MedNet |
| loratadine | WHO MedNet |
| loratadine | WHO MedNet |
| loratadinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester | ChEBI |
| BAY76-2211 | ChEMBL |
| NSC-758628 | ChEMBL |
| SCH 29851 | ChEMBL |
| SCH-29851 | ChEMBL |
| Brand Names | Source |
|---|---|
| Aerotina | ChemIDplus |
| Alarin | ChemIDplus |
| Alavert | DrugBank |
| Alerpriv | ChemIDplus |
| Allerclear | DrugBank |
| Children's claritin | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 1605 | DrugCentral |
| 3820 | ChemSpider |
| D00364 | KEGG DRUG |
| DB00455 | DrugBank |
| FDB023577 | FooDB |
| HMDB0005000 | HMDB |
| Loratadine | Wikipedia |
| LSM-5891 | LINCS |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4273483 | Reaxys |
| CAS:79794-75-5 | ChemIDplus |
| CAS:79794-75-5 | KEGG COMPOUND |
| Citations |
|---|