loratadine (CHEBI:6538)

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CHEBI:6538 - loratadine

ChEBI ID	CHEBI:6538
ChEBI Name	loratadine
Stars
Definition	A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H₁-receptor antagonist commonly employed in the treatment of allergic disorders.
Secondary ChEBI ID	CHEBI:94763
Last Modified	29 October 2021
Downloads	Molfile

Formula	C22H23ClN2O2
Net Charge	0
Average Mass	382.891
Monoisotopic Mass	382.14481
SMILES	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
InChI	InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChIKey	JCCNYMKQOSZNPW-UHFFFAOYSA-N

Wikipedia

Roles Classification

Biological Roles:

cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

H1-receptor antagonist H₁-receptor antagonists are the drugs that selectively bind to but do not activate histamine H₁ receptors, thereby blocking the actions of endogenous histamine.

Applications:

anti-allergic agent A drug used to treat allergic reactions.

geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

H1-receptor antagonist H₁-receptor antagonists are the drugs that selectively bind to but do not activate histamine H₁ receptors, thereby blocking the actions of endogenous histamine.

ChEBI Ontology

Outgoing Relation(s)
	loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342)
	loratadine (CHEBI:6538) has role anti-allergic agent (CHEBI:50857)
	loratadine (CHEBI:6538) has role cholinergic antagonist (CHEBI:48873)
	loratadine (CHEBI:6538) has role geroprotector (CHEBI:176497)
	loratadine (CHEBI:6538) has role H₁-receptor antagonist (CHEBI:37955)
	loratadine (CHEBI:6538) is a N-acylpiperidine (CHEBI:48591)
	loratadine (CHEBI:6538) is a benzocycloheptapyridine (CHEBI:48593)
	loratadine (CHEBI:6538) is a ethyl ester (CHEBI:23990)
	loratadine (CHEBI:6538) is a organochlorine compound (CHEBI:36683)
	loratadine (CHEBI:6538) is a tertiary carboxamide (CHEBI:140326)

IUPAC Name
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

INNs	Source
loratadina	WHO MedNet
loratadine	WHO MedNet
loratadine	WHO MedNet
loratadinum	WHO MedNet

Synonym	Source
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester	ChEBI

Brand Names	Source
Aerotina	ChemIDplus
Alarin	ChemIDplus
Alavert	DrugBank
Alerpriv	ChemIDplus
Allerclear	DrugBank
Civerán	ChemIDplus

Manual Xrefs	Databases
1605	DrugCentral
3820	ChemSpider
D00364	KEGG DRUG
DB00455	DrugBank
FDB023577	FooDB
HMDB0005000	HMDB
Loratadine	Wikipedia
LSM-5891	LINCS

Registry Numbers	Sources
Reaxys:4273483	Reaxys
CAS:79794-75-5	ChemIDplus
CAS:79794-75-5	KEGG COMPOUND

Citations