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CHEBI:291342 - desloratadine
| Formula | C19H19ClN2 |
| Net Charge | 0 |
| Average Mass | 310.828 |
| Monoisotopic Mass | 310.12368 |
| SMILES | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1 |
| InChI | InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| InChIKey | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. |
| Applications: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anti-allergic agent A drug used to treat allergic reactions. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| desloratadine (CHEBI:291342) has role anti-allergic agent (CHEBI:50857) |
| desloratadine (CHEBI:291342) has role antineoplastic agent (CHEBI:35610) |
| desloratadine (CHEBI:291342) has role cholinergic antagonist (CHEBI:48873) |
| desloratadine (CHEBI:291342) has role dermatologic drug (CHEBI:50177) |
| desloratadine (CHEBI:291342) has role drug metabolite (CHEBI:49103) |
| desloratadine (CHEBI:291342) has role H1-receptor antagonist (CHEBI:37955) |
| desloratadine (CHEBI:291342) has role immunosuppressive agent (CHEBI:35705) |
| desloratadine (CHEBI:291342) has role ophthalmology drug (CHEBI:66981) |
| desloratadine (CHEBI:291342) is a benzocycloheptapyridine (CHEBI:48593) |
| Incoming Relation(s) |
| loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342) |
| IUPAC Name |
|---|
| 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
| INNs | Source |
|---|---|
| desloratadina | WHO MedNet |
| desloratadine | KEGG DRUG |
| Synonyms | Source |
|---|---|
| 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | ChEMBL |
| 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine | ChemIDplus |
| Allex | ChEMBL |
| Dasselta | ChEMBL |
| Denosin | ChEMBL |
| descarboethoxyloratadine | ChemIDplus |
| Brand Names | Source |
|---|---|
| Aerius | ChEMBL |
| Clarinex | ChEMBL |
| Desloratadine actavis (authorized: rhinitis, urticaria) | ChEMBL |
| Desloratadine component of clarinex-d | ChEMBL |
| Desloratadine ratiopharm | ChEMBL |
| Desloratadine ratiopharm (authorized: rhinitis, urticaria) | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Beilstein:4263164 | Beilstein |
| CAS:100643-71-8 | KEGG DRUG |
| CAS:100643-71-8 | ChemIDplus |
| Citations |
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