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CHEBI:291342 - desloratadine

Default Structure
ChEBI IDCHEBI:291342
ChEBI Namedesloratadine
Stars
DefinitionLoratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
Last Modified29 October 2021
DownloadsMolfile
FormulaC19H19ClN2
Net Charge0
Average Mass310.828
Monoisotopic Mass310.12368
SMILESClc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1
InChIInChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChIKeyJAUOIFJMECXRGI-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
cholinergic antagonist  Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Applications:
anti-allergic agent  A drug used to treat allergic reactions.
cholinergic antagonist  Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
ChEBI Ontology
Outgoing Relation(s)
desloratadine (CHEBI:291342) has role anti-allergic agent (CHEBI:50857)
desloratadine (CHEBI:291342) has role cholinergic antagonist (CHEBI:48873)
desloratadine (CHEBI:291342) has role drug metabolite (CHEBI:49103)
desloratadine (CHEBI:291342) has role H1-receptor antagonist (CHEBI:37955)
desloratadine (CHEBI:291342) is a benzocycloheptapyridine (CHEBI:48593)
Incoming Relation(s)
loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342)
IUPAC Name 
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
INN  Source
desloratadineKEGG DRUG
Synonyms  Source
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridineChEMBL
8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridineChemIDplus
descarboethoxyloratadineChemIDplus
DESLORATADINEChEMBL
Manual XrefsDatabases
814DrugCentral
D03693KEGG DRUG
DB00967DrugBank
DesloratadineWikipedia
EP208855Patent
LSM-5887LINCS
US4659716Patent
Registry NumbersSources
Beilstein:4263164Beilstein
CAS:100643-71-8KEGG DRUG
CAS:100643-71-8ChemIDplus
Citations