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CHEBI:64358 - rivastigmine tartrate

ChEBI IDCHEBI:64358
ChEBI Namerivastigmine tartrate
Stars
DefinitionA tartrate salt obtained by reaction of rivastigmine with one equivalent of (R,R)-tartaric acid. A reversible cholinesterase inhibitor.
Last Modified11 April 2012
DownloadsMolfile
FormulaC14H22N2O2.C4H6O6
Net Charge0
Average Mass400.428
Monoisotopic Mass400.18457
SMILESCCN(C)C(=O)Oc1cccc([C@H](C)N(C)C)c1.O=C(O)[C@H](O)[C@@H](O)C(=O)O
InChIInChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
InChIKeyGWHQHAUAXRMMOT-MBANBULQSA-N
Roles Classification
Biological Roles:
EC 3.1.1.8 (cholinesterase) inhibitor  An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
cholinergic drug  Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
Applications:
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
cholinergic drug  Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
ChEBI Ontology
Outgoing Relation(s)
rivastigmine tartrate (CHEBI:64358) has part rivastigmine(1+) (CHEBI:64363)
rivastigmine tartrate (CHEBI:64358) has role cholinergic drug (CHEBI:38323)
rivastigmine tartrate (CHEBI:64358) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733)
rivastigmine tartrate (CHEBI:64358) has role neuroprotective agent (CHEBI:63726)
rivastigmine tartrate (CHEBI:64358) is a tartrate salt (CHEBI:50562)
IUPAC Name 
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate (2R,3R)-2,3-dihydroxybutanedioate
Synonyms  Source
rivastigmine hydrogen tartrateDrugBank
SDZ-ENA 713ChemIDplus
(1S)-1-(3-{[ethyl(methyl)carbamoyl]oxy}phenyl)-N,N-dimethylethanaminium (2R,3R)-3-carboxy-2,3-dihydroxypropanoateIUPAC
Brand Name  Source
ExelonKEGG DRUG
Manual XrefsDatabases
D02558KEGG DRUG
DB00989DrugBank
EP1980552Patent
US2008255383Patent
EP2233465Patent
US2008306280Patent
Registry NumbersSources
Reaxys:9305032Reaxys
CAS:129101-54-8ChemIDplus
CAS:129101-54-8KEGG DRUG
Citations