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CHEBI:64195 - ritanserin

ChEBI IDCHEBI:64195
ChEBI Nameritanserin
Stars
DefinitionA thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.
Last Modified25 February 2016
SubmitterGareth Owen
DownloadsMolfile
FormulaC27H25F2N3OS
Net Charge0
Average Mass477.580
Monoisotopic Mass477.16864
SMILESCc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIInChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
InChIKeyJUQLTPCYUFPYKE-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor  Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
antipsychotic agent  Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
ChEBI Ontology
Outgoing Relation(s)
ritanserin (CHEBI:64195) has role antidepressant (CHEBI:35469)
ritanserin (CHEBI:64195) has role antipsychotic agent (CHEBI:35476)
ritanserin (CHEBI:64195) has role anxiolytic drug (CHEBI:35474)
ritanserin (CHEBI:64195) has role dopaminergic antagonist (CHEBI:48561)
ritanserin (CHEBI:64195) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779)
ritanserin (CHEBI:64195) has role serotonergic antagonist (CHEBI:48279)
ritanserin (CHEBI:64195) is a organofluorine compound (CHEBI:37143)
ritanserin (CHEBI:64195) is a piperidines (CHEBI:26151)
ritanserin (CHEBI:64195) is a thiazolopyrimidine (CHEBI:64196)
IUPAC Name 
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
INNs  Source
ritanserineChemIDplus
ritanserinaChemIDplus
ritanserinChemIDplus
ritanserinumChemIDplus
Synonyms  Source
R 55,667ChemIDplus
6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-oneChemIDplus
R-55667ChEBI
Manual XrefsDatabases
D05738KEGG DRUG
RitanserinWikipedia
US4533665Patent
LSM-2906LINCS
Registry NumbersSources
Reaxys:4913835Reaxys
CAS:87051-43-2ChemIDplus
Citations