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CHEBI:6343 - labetalol
| ChEBI ID | CHEBI:6343 |
| ChEBI Name | labetalol |
| Stars | |
| Definition | A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure. |
| Last Modified | 27 April 2022 |
| Formula | C19H24N2O3 |
| Net Charge | 0 |
| Average Mass | 328.412 |
| Monoisotopic Mass | 328.17869 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| labetalol (CHEBI:6343) has part (R,R)-labetalol (CHEBI:94471) |
| labetalol (CHEBI:6343) has part (R,S)-labetolol (CHEBI:167640) |
| labetalol (CHEBI:6343) has part (S,R)-labetolol (CHEBI:167641) |
| labetalol (CHEBI:6343) has part (S,S)-labetalol (CHEBI:167639) |
| labetalol (CHEBI:6343) has role analgesic (CHEBI:35480) |
| labetalol (CHEBI:6343) has role antihypertensive agent (CHEBI:35674) |
| labetalol (CHEBI:6343) has role cardiovascular drug (CHEBI:35554) |
| labetalol (CHEBI:6343) has role sympatholytic agent (CHEBI:66991) |
| labetalol (CHEBI:6343) has role α-adrenergic antagonist (CHEBI:37890) |
| labetalol (CHEBI:6343) has role β-adrenergic antagonist (CHEBI:35530) |
| labetalol (CHEBI:6343) is a diastereoisomeric mixture (CHEBI:60915) |
| IUPAC Name |
|---|
| 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide |
| INNs | Source |
|---|---|
| labetalol | ChEBI |
| labétalol | ChEBI |
| labetalolum | ChEBI |
| Synonyms | Source |
|---|---|
| 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol | ChemIDplus |
| 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide | ChemIDplus |
| AH-5158A FREE BASE | ChEMBL |
| kabetalol | ChEBI |
| Labetalol | KEGG COMPOUND |
| Normozide | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2948416 | Reaxys |
| CAS:36894-69-6 | NIST Chemistry WebBook |
| CAS:36894-69-6 | ChemIDplus |
| Citations |
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