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CHEBI:6130 - ketorolac tromethamine

Default Structure
ChEBI IDCHEBI:6130
ChEBI Nameketorolac tromethamine
Stars
DefinitionAn organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Last Modified8 November 2013
DownloadsMolfile
FormulaC15H12NO3.C4H12NO3
Net Charge0
Average Mass376.409
Monoisotopic Mass376.16344
SMILESO=C(c1ccccc1)c1ccc2n1CCC2C(=O)[O-].[NH3+]C(CO)(CO)CO
InChIInChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChIKeyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Roles Classification
Biological Roles:
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
Applications:
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
ophthalmology drug  Any compound used for the treatment of eye conditions or eye diseases.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
ChEBI Ontology
Outgoing Relation(s)
ketorolac tromethamine (CHEBI:6130) has part Htris (CHEBI:46097)
ketorolac tromethamine (CHEBI:6130) has part ketorolac(1−) (CHEBI:76229)
ketorolac tromethamine (CHEBI:6130) has role analgesic (CHEBI:35480)
ketorolac tromethamine (CHEBI:6130) has role anti-inflammatory agent (CHEBI:67079)
ketorolac tromethamine (CHEBI:6130) has role antineoplastic agent (CHEBI:35610)
ketorolac tromethamine (CHEBI:6130) has role cardiovascular drug (CHEBI:35554)
ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
ketorolac tromethamine (CHEBI:6130) has role ophthalmology drug (CHEBI:66981)
ketorolac tromethamine (CHEBI:6130) is a organoammonium salt (CHEBI:46850)
IUPAC Name 
1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
Synonyms  Source
Ketorolac (+/-)-form tromethamine saltChEMBL
NSC-758637ChEMBL
TarasynChEMBL
Brand Names  Source
AcularKEGG DRUG
Acular lsChEMBL
Acular preservative freeChEMBL
AcuvailChEBI
DolacChEBI
Ketorolac tromethamine component of omidriaChEMBL
Manual XrefsDatabases
D00813KEGG DRUG
DB00465DrugBank
HMDB0014608HMDB
Registry NumbersSources
Reaxys:6463165Reaxys
CAS:74103-07-4KEGG DRUG
CAS:74103-07-4ChemIDplus
Citations