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CHEBI:6130 - ketorolac tromethamine

ChEBI IDCHEBI:6130
ChEBI Nameketorolac tromethamine
Stars
DefinitionAn organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Last Modified8 November 2013
DownloadsMolfile
FormulaC15H12NO3.C4H12NO3
Net Charge0
Average Mass376.409
Monoisotopic Mass376.16344
SMILESO=C(c1ccccc1)c1ccc2n1CCC2C(=O)[O-].[NH3+]C(CO)(CO)CO
InChIInChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChIKeyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Roles Classification
Biological Roles:
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
Application:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
ChEBI Ontology
Outgoing Relation(s)
ketorolac tromethamine (CHEBI:6130) has part Htris (CHEBI:46097)
ketorolac tromethamine (CHEBI:6130) has part ketorolac(1−) (CHEBI:76229)
ketorolac tromethamine (CHEBI:6130) has role analgesic (CHEBI:35480)
ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
ketorolac tromethamine (CHEBI:6130) is a organoammonium salt (CHEBI:46850)
IUPAC Name 
1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
Brand Names  Source
ToradolKEGG DRUG
AcularKEGG DRUG
AcuvailChEBI
DolacChEBI
LixidolChEBI
SprixChEBI
Manual XrefsDatabases
D00813KEGG DRUG
DB00465DrugBank
HMDB0014608HMDB
Registry NumbersSources
Reaxys:6463165Reaxys
CAS:74103-07-4ChemIDplus
CAS:74103-07-4KEGG DRUG
Citations