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CHEBI:60799 - esketamine
| Formula | C13H16ClNO |
| Net Charge | 0 |
| Average Mass | 237.730 |
| Monoisotopic Mass | 237.09204 |
| SMILES | CN[C@]1(c2ccccc2Cl)CCCCC1=O |
| InChI | InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3/t13-/m0/s1 |
| InChIKey | YQEZLKZALYSWHR-ZDUSSCGKSA-N |
| Roles Classification |
|---|
| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. anti-obesity agent Any substance which is used to reduce or control weight. NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antiviral agent A substance that destroys or inhibits replication of viruses. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. neurotoxin A poison that interferes with the functions of the nervous system. |
| Applications: | renoprotective agent Any compound that is able to prevent damage to the kidneys. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antiparkinson drug A drug used in the treatment of Parkinson's disease. vulnerary A drug used in treating and healing of wounds. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. anticonvulsant A drug used to prevent seizures or reduce their severity. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| esketamine (CHEBI:60799) has role analgesic (CHEBI:35480) |
| esketamine (CHEBI:60799) has role antidepressant (CHEBI:35469) |
| esketamine (CHEBI:60799) has role intravenous anaesthetic (CHEBI:38877) |
| esketamine (CHEBI:60799) has role NMDA receptor antagonist (CHEBI:60643) |
| esketamine (CHEBI:60799) has role renoprotective agent (CHEBI:231911) |
| esketamine (CHEBI:60799) is a ketamine (CHEBI:6121) |
| esketamine (CHEBI:60799) is enantiomer of (R)-ketamine (CHEBI:580604) |
| Incoming Relation(s) |
| esketamine hydrochloride (CHEBI:60800) has part esketamine (CHEBI:60799) |
| (R)-ketamine (CHEBI:580604) is enantiomer of esketamine (CHEBI:60799) |
| IUPAC Name |
|---|
| (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone |
| INNs | Source |
|---|---|
| esketamina | WHO MedNet |
| esketamine | ChemIDplus |
| Synonyms | Source |
|---|---|
| (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone | ChemIDplus |
| (S)-(−)-ketamine | ChemIDplus |
| (S)-ketamine | ChemIDplus |
| Jnj-54135419 | ChEMBL |
| (−)-ketamine | ChemIDplus |
| Ketamine, (s)- | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4295313 | Reaxys |
| CAS:33643-46-8 | ChemIDplus |
| CAS:33643-46-8 | KEGG DRUG |
| Citations |
|---|