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CHEBI:59880 - encainide hydrochloride

ChEBI IDCHEBI:59880
ChEBI Nameencainide hydrochloride
Stars
DefinitionThe hydrochloride salt of encainide. A class Ic antiarrhythmic, it was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.
Last Modified27 July 2010
SubmitterGareth Owen
DownloadsMolfile
FormulaC22H28N2O2.HCl
Net Charge0
Average Mass388.939
Monoisotopic Mass388.19176
SMILESCOc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1.Cl
InChIInChI=1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H
InChIKeyOJIIZIWOLTYOBS-UHFFFAOYSA-N
Roles Classification
Application:
anti-arrhythmia drug  A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
ChEBI Ontology
Outgoing Relation(s)
encainide hydrochloride (CHEBI:59880) has part encainide (CHEBI:4788)
encainide hydrochloride (CHEBI:59880) has role anti-arrhythmia drug (CHEBI:38070)
encainide hydrochloride (CHEBI:59880) is a hydrochloride (CHEBI:36807)
IUPAC Name 
2-(2-{2-[(4-methoxybenzoyl)amino]phenyl}ethyl)-1-methylpiperidinium chloride
Synonyms  Source
encainide HClChemIDplus
4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide hydrochlorideIUPAC
(±)-2'-(2-(1-methyl-2-piperidyl)ethyl)-p-anisanilide monohydrochlorideChemIDplus
4-methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide hydrochlorideChemIDplus
Manual XrefsDatabases
D03991KEGG DRUG
DB01228DrugBank
Registry NumbersSources
Beilstein:6360008Beilstein
CAS:66794-74-9KEGG DRUG
CAS:66794-74-9ChemIDplus