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CHEBI:59788 - diphenylpyraline

Default Structure
ChEBI IDCHEBI:59788
ChEBI Namediphenylpyraline
Stars
DefinitionA member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Last Modified22 February 2017
SubmitterGareth Owen
DownloadsMolfile
FormulaC19H23NO
Net Charge0
Average Mass281.399
Monoisotopic Mass281.17796
SMILESCN1CCC(OC(c2ccccc2)c2ccccc2)CC1
InChIInChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
InChIKeyOWQUZNMMYNAXSL-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist  Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
Applications:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist  Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
ChEBI Ontology
Outgoing Relation(s)
diphenylpyraline (CHEBI:59788) has role cholinergic antagonist (CHEBI:48873)
diphenylpyraline (CHEBI:59788) has role H1-receptor antagonist (CHEBI:37955)
diphenylpyraline (CHEBI:59788) is a piperidines (CHEBI:26151)
diphenylpyraline (CHEBI:59788) is a tertiary amine (CHEBI:32876)
Incoming Relation(s)
diphenylpyraline hydrochloride (CHEBI:31508) has part diphenylpyraline (CHEBI:59788)
IUPAC Name 
4-(diphenylmethoxy)-1-methylpiperidine
INNs  Source
difenilpiralinaChemIDplus
diphenylpyralineChemIDplus
diphenylpyralinumChemIDplus
Synonyms  Source
1-methyl-4-hydroxypiperidine benzhydryl etherChEBI
1-methyl-4-piperidyl benzhydryl etherChemIDplus
4-(benzhydryloxy)-1-methylpiperidineChemIDplus
4-(benzhydryloxy)-N-methylpiperidineChEBI
diphenylpyralamineDrugBank
Manual XrefsDatabases
920DrugCentral
D07862KEGG DRUG
DB01146DrugBank
DiphenylpyralineWikipedia
HMDB0015277HMDB
LSM-5385LINCS
US2479843Patent
Registry NumbersSources
Reaxys:245467Reaxys
CAS:147-20-6NIST Chemistry WebBook
CAS:147-20-6ChemIDplus
CAS:147-20-6KEGG DRUG
Citations