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CHEBI:5818 - hydroxyzine

Default Structure
ChEBI IDCHEBI:5818
ChEBI Namehydroxyzine
Stars
DefinitionA N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Last Modified23 April 2020
DownloadsMolfile
FormulaC21H27ClN2O2
Net Charge0
Average Mass374.912
Monoisotopic Mass374.17611
SMILESOCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChIInChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
InChIKeyZQDWXGKKHFNSQK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Applications:
antipruritic drug  A drug, usually applied topically, that relieves pruritus (itching).
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
dermatologic drug  A drug used to treat or prevent skin disorders or for the routine care of skin.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
ChEBI Ontology
Outgoing Relation(s)
hydroxyzine (CHEBI:5818) has role anticoronaviral agent (CHEBI:149553)
hydroxyzine (CHEBI:5818) has role antipruritic drug (CHEBI:59683)
hydroxyzine (CHEBI:5818) has role anxiolytic drug (CHEBI:35474)
hydroxyzine (CHEBI:5818) has role dermatologic drug (CHEBI:50177)
hydroxyzine (CHEBI:5818) has role H1-receptor antagonist (CHEBI:37955)
hydroxyzine (CHEBI:5818) is a N-alkylpiperazine (CHEBI:46845)
hydroxyzine (CHEBI:5818) is a hydroxyether (CHEBI:46789)
hydroxyzine (CHEBI:5818) is a monochlorobenzenes (CHEBI:83403)
Incoming Relation(s)
hydroxyzine hydrochloride (CHEBI:5819) has part hydroxyzine (CHEBI:5818)
hydroxyzine pamoate (CHEBI:31680) has part hydroxyzine (CHEBI:5818)
IUPAC Name 
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
INNs  Source
hidroxizinaChemIDplus
hydroxyzineChemIDplus
hydroxyzinumChemIDplus
Synonyms  Source
HychotineChemIDplus
HydroxineChemIDplus
HydroxizineChemIDplus
HydroxizinumChemIDplus
HydroxycineChemIDplus
HydroxyzinChemIDplus
Manual XrefsDatabases
1400DrugCentral
2977VSDB
C07045KEGG COMPOUND
D08054KEGG DRUG
DB00557DrugBank
HMDB0014697HMDB
HydroxyzineWikipedia
LSM-5103LINCS
US2899436Patent
Registry NumbersSources
Reaxys:321392Reaxys
CAS:68-88-2KEGG COMPOUND
CAS:68-88-2ChemIDplus
Citations