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CHEBI:5818 - hydroxyzine

ChEBI IDCHEBI:5818
ChEBI Namehydroxyzine
Stars
DefinitionA N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Last Modified23 April 2020
DownloadsMolfile
FormulaC21H27ClN2O2
Net Charge0
Average Mass374.912
Monoisotopic Mass374.17611
SMILESOCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChIInChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
InChIKeyZQDWXGKKHFNSQK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
Applications:
antipruritic drug  A drug, usually applied topically, that relieves pruritus (itching).
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
dermatologic drug  A drug used to treat or prevent skin disorders or for the routine care of skin.
ChEBI Ontology
Outgoing Relation(s)
hydroxyzine (CHEBI:5818) has role anticoronaviral agent (CHEBI:149553)
hydroxyzine (CHEBI:5818) has role antipruritic drug (CHEBI:59683)
hydroxyzine (CHEBI:5818) has role anxiolytic drug (CHEBI:35474)
hydroxyzine (CHEBI:5818) has role dermatologic drug (CHEBI:50177)
hydroxyzine (CHEBI:5818) has role H1-receptor antagonist (CHEBI:37955)
hydroxyzine (CHEBI:5818) is a N-alkylpiperazine (CHEBI:46845)
hydroxyzine (CHEBI:5818) is a hydroxyether (CHEBI:46789)
hydroxyzine (CHEBI:5818) is a monochlorobenzenes (CHEBI:83403)
Incoming Relation(s)
hydroxyzine hydrochloride (CHEBI:5819) has part hydroxyzine (CHEBI:5818)
hydroxyzine pamoate (CHEBI:31680) has part hydroxyzine (CHEBI:5818)
IUPAC Name 
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
INNs  Source
hidroxizinaChemIDplus
hydroxyzineChemIDplus
hydroxyzinumChemIDplus
Synonyms  Source
HydroxyzineKEGG COMPOUND
HychotineChemIDplus
HydroxineChemIDplus
HydroxizineChemIDplus
HydroxizinumChemIDplus
HydroxycineChemIDplus
Manual XrefsDatabases
C07045KEGG COMPOUND
DB00557DrugBank
US2899436Patent
HydroxyzineWikipedia
HMDB0014697HMDB
D08054KEGG DRUG
LSM-5103LINCS
1400DrugCentral
2977VSDB
Registry NumbersSources
Reaxys:321392Reaxys
CAS:68-88-2KEGG COMPOUND
CAS:68-88-2ChemIDplus
Citations