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CHEBI:5801 - hydroxychloroquine
| Formula | C18H26ClN3O |
| Net Charge | 0 |
| Average Mass | 335.879 |
| Monoisotopic Mass | 335.17644 |
| SMILES | CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 |
| InChI | InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21) |
| InChIKey | XXSMGPRMXLTPCZ-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. antiviral agent A substance that destroys or inhibits replication of viruses. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. |
| Applications: | insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). hypoglycemic agent A drug which lowers the blood glucose level. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. anti-inflammatory agent Any compound that has anti-inflammatory effects. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antirheumatic drug A drug used to treat rheumatoid arthritis. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| hydroxychloroquine (CHEBI:5801) has functional parent chloroquine (CHEBI:3638) |
| hydroxychloroquine (CHEBI:5801) has role anti-HIV agent (CHEBI:64946) |
| hydroxychloroquine (CHEBI:5801) has role anti-inflammatory agent (CHEBI:67079) |
| hydroxychloroquine (CHEBI:5801) has role anticoronaviral agent (CHEBI:149553) |
| hydroxychloroquine (CHEBI:5801) has role antifungal agent (CHEBI:35718) |
| hydroxychloroquine (CHEBI:5801) has role antiinfective agent (CHEBI:35441) |
| hydroxychloroquine (CHEBI:5801) has role antimalarial (CHEBI:38068) |
| hydroxychloroquine (CHEBI:5801) has role antimicrobial agent (CHEBI:33281) |
| hydroxychloroquine (CHEBI:5801) has role antineoplastic agent (CHEBI:35610) |
| hydroxychloroquine (CHEBI:5801) has role antirheumatic drug (CHEBI:35842) |
| hydroxychloroquine (CHEBI:5801) has role antiviral agent (CHEBI:22587) |
| hydroxychloroquine (CHEBI:5801) has role dermatologic drug (CHEBI:50177) |
| hydroxychloroquine (CHEBI:5801) has role hypoglycemic agent (CHEBI:35526) |
| hydroxychloroquine (CHEBI:5801) has role immunosuppressive agent (CHEBI:35705) |
| hydroxychloroquine (CHEBI:5801) has role insulin-sensitizing drug (CHEBI:50864) |
| hydroxychloroquine (CHEBI:5801) is a aminoquinoline (CHEBI:36709) |
| hydroxychloroquine (CHEBI:5801) is a organochlorine compound (CHEBI:36683) |
| hydroxychloroquine (CHEBI:5801) is a primary alcohol (CHEBI:15734) |
| hydroxychloroquine (CHEBI:5801) is a secondary amino compound (CHEBI:50995) |
| hydroxychloroquine (CHEBI:5801) is a tertiary amino compound (CHEBI:50996) |
| hydroxychloroquine (CHEBI:5801) is conjugate base of hydroxychloroquine(2+) (CHEBI:149564) |
| Incoming Relation(s) |
| hydroxychloroquine(2+) (CHEBI:149564) is conjugate acid of hydroxychloroquine (CHEBI:5801) |
| IUPAC Name |
|---|
| 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol |
| INNs | Source |
|---|---|
| hidroxicloroquina | ChemIDplus |
| hydroxychloroquine | ChemIDplus |
| hydroxychloroquine | WHO MedNet |
| hydroxychloroquinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol | ChemIDplus |
| 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol | ChemIDplus |
| 7-chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline | ChemIDplus |
| 7-chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline | ChEBI |
| 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline | ChemIDplus |
| 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline | ChEBI |
| Brand Name | Source |
|---|---|
| Polirreumin | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| 1395 | DrugCentral |
| C07043 | KEGG COMPOUND |
| D08050 | KEGG DRUG |
| DB01611 | DrugBank |
| HMDB0015549 | HMDB |
| Hydroxychloroquine | Wikipedia |
| LSM-5193 | LINCS |
| US2546658 | Patent |
| Citations |
|---|