CHEBI:5775 - hydralazine

ChEBI IDCHEBI:5775
ChEBI Namehydralazine
Stars
DefinitionThe 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Last Modified18 September 2026
DownloadsMolfile
FormulaC8H8N4
Net Charge0
Average Mass160.180
Monoisotopic Mass160.07490
SMILESNNc1nncc2ccccc12
InChIInChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
InChIKeyRPTUSVTUFVMDQK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
vasodilator agent  A drug used to cause dilation of the blood vessels.
antiatherosclerotic agent  A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
ChEBI Ontology
Outgoing Relation(s)
hydralazine (CHEBI:5775) has role antiatherosclerotic agent (CHEBI:145947)
hydralazine (CHEBI:5775) has role antihypertensive agent (CHEBI:35674)
hydralazine (CHEBI:5775) has role antineoplastic agent (CHEBI:35610)
hydralazine (CHEBI:5775) has role cardiovascular drug (CHEBI:35554)
hydralazine (CHEBI:5775) has role hypoglycemic agent (CHEBI:35526)
hydralazine (CHEBI:5775) has role vasodilator agent (CHEBI:35620)
hydralazine (CHEBI:5775) is a ortho-fused heteroarene (CHEBI:52362)
hydralazine (CHEBI:5775) is a azaarene (CHEBI:50893)
hydralazine (CHEBI:5775) is a hydrazines (CHEBI:24631)
hydralazine (CHEBI:5775) is a phthalazines (CHEBI:38768)
Incoming Relation(s)
N-acetylhydralazine (CHEBI:760906) has functional parent hydralazine (CHEBI:5775)
hydralazine hydrochloride (CHEBI:31672) has part hydralazine (CHEBI:5775)
IUPAC Name 
1-hydrazinophthalazine
INNs  Source
hidralazinaChemIDplus
hydralazineKEGG DRUG
hydralazinumChemIDplus
Synonyms  Source
1-HydrazinophthalazineChemIDplus
1-PhthalazinylhydrazineChemIDplus
(1Z)-1(2H)-Phthalazinone hydrazoneNIST Chemistry WebBook
(2H)-Phthalazinone hydrazoneChemIDplus
6-HydralazineChemIDplus
HydralazinChemIDplus
UniProt Name  Source
hydralazineUniProt
Manual XrefsDatabases
1384DrugCentral
C07040KEGG COMPOUND
D08044KEGG DRUG
DB01275DrugBank
HydralazineWikipedia
LSM-15370LINCS
US2484029Patent
Registry NumbersSources
Beilstein:132615Beilstein
Gmelin:4337Gmelin
CAS:86-54-4KEGG COMPOUND
CAS:86-54-4NIST Chemistry WebBook
CAS:86-54-4ChemIDplus
Citations