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CHEBI:5557 - guanethidine

Default Structure
ChEBI IDCHEBI:5557
ChEBI Nameguanethidine
Stars
DefinitionA member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
Last Modified22 February 2017
DownloadsMolfile
FormulaC10H22N4
Net Charge0
Average Mass198.314
Monoisotopic Mass198.18445
SMILESN=C(N)NCCN1CCCCCCC1
InChIInChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)
InChIKeyACGDKVXYNVEAGU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
adrenergic antagonist  An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
sympatholytic agent  Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
Applications:
antiglaucoma drug  Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
adrenergic antagonist  An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
sympatholytic agent  Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
ChEBI Ontology
Outgoing Relation(s)
guanethidine (CHEBI:5557) has functional parent guanidine (CHEBI:42820)
guanethidine (CHEBI:5557) has parent hydride azocane (CHEBI:38792)
guanethidine (CHEBI:5557) has role adrenergic antagonist (CHEBI:37887)
guanethidine (CHEBI:5557) has role antiglaucoma drug (CHEBI:39456)
guanethidine (CHEBI:5557) has role antihypertensive agent (CHEBI:35674)
guanethidine (CHEBI:5557) has role sympatholytic agent (CHEBI:66991)
guanethidine (CHEBI:5557) is a azocanes (CHEBI:38791)
guanethidine (CHEBI:5557) is a guanidines (CHEBI:24436)
Incoming Relation(s)
guanethidine monosulfate (CHEBI:51016) has part guanethidine (CHEBI:5557)
IUPAC Name 
1-(2-azocan-1-ylethyl)guanidine
INNs  Source
guanethidineChEBI
guanéthidineChEBI
guanethidinumChEBI
guanetidinaChEBI
Synonyms  Source
2-(1'-Azacyclooctyl)ethylguanidineChemIDplus
2-(1-N,N-Heptamethyleneimino)ethylguanidineChemIDplus
(2-(Octahydro-1-azocinyl)ethyl)guanidineChemIDplus
Azocine, 1-(2-guanidinoethyl)octahydro-ChemIDplus
N-(2-Perhydroazocin-1-ylethyl)guanidineChemIDplus
GuanethidineKEGG COMPOUND
Manual XrefsDatabases
1342DrugCentral
C07036KEGG COMPOUND
D08030KEGG DRUG
DB01170DrugBank
GuanethidineWikipedia
HMDB0015301HMDB
LSM-6719LINCS
US2928829Patent
Registry NumbersSources
Reaxys:1343950Reaxys
CAS:55-65-2ChemIDplus
Citations