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CHEBI:5557 - guanethidine

ChEBI IDCHEBI:5557
ChEBI Nameguanethidine
Stars
DefinitionA member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
Last Modified22 February 2017
DownloadsMolfile
FormulaC10H22N4
Net Charge0
Average Mass198.314
Monoisotopic Mass198.18445
SMILESN=C(N)NCCN1CCCCCCC1
InChIInChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)
InChIKeyACGDKVXYNVEAGU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
sympatholytic agent  Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
adrenergic antagonist  An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
sympatholytic agent  Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
adrenergic antagonist  An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
ChEBI Ontology
Outgoing Relation(s)
guanethidine (CHEBI:5557) has functional parent guanidine (CHEBI:42820)
guanethidine (CHEBI:5557) has parent hydride azocane (CHEBI:38792)
guanethidine (CHEBI:5557) has role adrenergic antagonist (CHEBI:37887)
guanethidine (CHEBI:5557) has role antihypertensive agent (CHEBI:35674)
guanethidine (CHEBI:5557) has role sympatholytic agent (CHEBI:66991)
guanethidine (CHEBI:5557) is a azocanes (CHEBI:38791)
guanethidine (CHEBI:5557) is a guanidines (CHEBI:24436)
Incoming Relation(s)
guanethidine monosulfate (CHEBI:51016) has part guanethidine (CHEBI:5557)
IUPAC Name 
1-(2-azocan-1-ylethyl)guanidine
INNs  Source
guanethidineChEBI
guanéthidineChEBI
guanetidinaChEBI
guanethidinumChEBI
Synonyms  Source
GuanethidineKEGG COMPOUND
(2-(Octahydro-1-azocinyl)ethyl)guanidineChemIDplus
2-(1'-Azacyclooctyl)ethylguanidineChemIDplus
2-(1-N,N-Heptamethyleneimino)ethylguanidineChemIDplus
Azocine, 1-(2-guanidinoethyl)octahydro-ChemIDplus
Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-ChemIDplus
Manual XrefsDatabases
C07036KEGG COMPOUND
DB01170DrugBank
US2928829Patent
GuanethidineWikipedia
HMDB0015301HMDB
D08030KEGG DRUG
LSM-6719LINCS
1342DrugCentral
Registry NumbersSources
Reaxys:1343950Reaxys
CAS:55-65-2ChemIDplus
Citations