EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:55362 - (R)-azelastine

ChEBI IDCHEBI:55362
ChEBI Name(R)-azelastine
Stars
ASCII Name(R)-azelastine
DefinitionThe (R)-enantiomer of azelastine.
Last Modified24 August 2012
SubmitterSteve
DownloadsMolfile
FormulaC22H24ClN3O
Net Charge0
Average Mass381.907
Monoisotopic Mass381.16079
SMILESCN1CCC[C@@H](n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1
InChIInChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3/t18-/m1/s1
InChIKeyMBUVEWMHONZEQD-GOSISDBHSA-N
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor  A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Applications:
anti-allergic agent  A drug used to treat allergic reactions.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
anti-asthmatic drug  A drug used to treat asthma.
bronchodilator agent  An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
ChEBI Ontology
Outgoing Relation(s)
(R)-azelastine (CHEBI:55362) is a azelastine (CHEBI:2950)
(R)-azelastine (CHEBI:55362) is enantiomer of (S)-azelastine (CHEBI:55363)
Incoming Relation(s)
(S)-azelastine (CHEBI:55363) is enantiomer of (R)-azelastine (CHEBI:55362)
IUPAC Name 
4-(4-chlorobenzyl)-2-[(4R)-1-methylazepan-4-yl]phthalazin-1(2H)-one