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CHEBI:52724 - PS-519

ChEBI IDCHEBI:52724
ChEBI NamePS-519
Stars
DefinitionA β-lactone proteasome inhibitor derived from lactacystin.
Last Modified8 July 2009
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC12H19NO4
Net Charge0
Average Mass241.287
Monoisotopic Mass241.13141
SMILESCCC[C@H]1C(=O)N[C@@]2([C@@H](O)C(C)C)C(=O)O[C@@H]12
InChIInChI=1S/C12H19NO4/c1-4-5-7-9-12(11(16)17-9,13-10(7)15)8(14)6(2)3/h6-9,14H,4-5H2,1-3H3,(H,13,15)/t7-,8+,9+,12-/m1/s1
InChIKeyKMXHEXRPYSXLRN-JDVQERKKSA-N
Roles Classification
Application:
proteasome inhibitor  A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
ChEBI Ontology
Outgoing Relation(s)
PS-519 (CHEBI:52724) has functional parent lactacystin (CHEBI:52722)
PS-519 (CHEBI:52724) has role proteasome inhibitor (CHEBI:52726)
PS-519 (CHEBI:52724) is a lactam (CHEBI:24995)
PS-519 (CHEBI:52724) is a β-lactone (CHEBI:49043)
IUPAC Name 
(1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Registry NumbersSources
Beilstein:8492768Beilstein