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CHEBI:51241 - carphenazine maleate

ChEBI IDCHEBI:51241
ChEBI Namecarphenazine maleate
Stars
DefinitionA maleate salt obtained by combining carphenazine with two molar equivalents of maleic acid.
Last Modified19 March 2021
SubmitterInma Spiteri
DownloadsMolfile
FormulaC24H31N3O2S.2C4H4O4
Net Charge0
Average Mass657.742
Monoisotopic Mass657.23562
SMILESCCC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O
InChIInChI=1S/C24H31N3O2S.2C4H4O4/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28;2*5-3(6)1-2-4(7)8/h3-4,6-9,18,28H,2,5,10-17H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChIKeyTVPJGGZLZLUPOB-SPIKMXEPSA-N
Roles Classification
Biological Role:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Applications:
antiemetic  A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
ChEBI Ontology
Outgoing Relation(s)
carphenazine maleate (CHEBI:51241) has part carfenazine (CHEBI:51235)
carphenazine maleate (CHEBI:51241) has role antiemetic (CHEBI:50919)
carphenazine maleate (CHEBI:51241) has role dopaminergic antagonist (CHEBI:48561)
carphenazine maleate (CHEBI:51241) has role phenothiazine antipsychotic drug (CHEBI:37930)
carphenazine maleate (CHEBI:51241) is a maleate salt (CHEBI:50221)
IUPAC Name 
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)propan-1-one di[(2Z)-but-2-enedioate]
Synonyms  Source
1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl)-1-propanone maleate(1:2)ChemIDplus
1-Propanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)-, (Z)-2-butenedioate (1:2)ChemIDplus
Carfenazine maleateChemIDplus
Carphenazine dimaleateChemIDplus
WY-2445ChemIDplus
proketazine dimaleateChemIDplus
Brand Name  Source
ProketazineChemIDplus
Manual XrefsDatabases
D02644KEGG DRUG
DBSALT001419DrugBank
4938524ChemSpider
Registry NumbersSources
Beilstein:5709373Beilstein
Reaxys:15397689Reaxys
CAS:2975-34-0ChemIDplus
Citations