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CHEBI:51235 - carfenazine

ChEBI IDCHEBI:51235
ChEBI Namecarfenazine
Stars
DefinitionA member of the class of phenothiazines that is 10H-phenothiazine which carries a propanoyl group at position 2 and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at position N-10. It is an antipsychotic drug that is used for the treatment of chronic schizophrenia.
Last Modified19 March 2021
SubmitterInma Spiteri
DownloadsMolfile
FormulaC24H31N3O2S
Net Charge0
Average Mass425.598
Monoisotopic Mass425.21370
SMILESCCC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2
InChIInChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3
InChIKeyXZSMZRXAEFNJCU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Applications:
antiemetic  A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
ChEBI Ontology
Outgoing Relation(s)
carfenazine (CHEBI:51235) has role antiemetic (CHEBI:50919)
carfenazine (CHEBI:51235) has role dopaminergic antagonist (CHEBI:48561)
carfenazine (CHEBI:51235) has role phenothiazine antipsychotic drug (CHEBI:37930)
carfenazine (CHEBI:51235) is a N-(2-hydroxyethyl)piperazine (CHEBI:46851)
carfenazine (CHEBI:51235) is a N-alkylpiperazine (CHEBI:46845)
carfenazine (CHEBI:51235) is a aromatic ketone (CHEBI:76224)
carfenazine (CHEBI:51235) is a phenothiazines (CHEBI:38093)
Incoming Relation(s)
carphenazine maleate (CHEBI:51241) has part carfenazine (CHEBI:51235)
IUPAC Name 
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)propan-1-one
INNs  Source
carfenazineWHO MedNet
carfénazineWHO MedNet
carfenazinaWHO MedNet
carfenazinumWHO MedNet
Synonyms  Source
1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl)-1-propanoneChemIDplus
carphenazineChemIDplus
Manual XrefsDatabases
DB01038DrugBank
US2985654Patent
US3023146Patent
CarphenazineWikipedia
516DrugCentral
HMDB0015172HMDB
21865853ChemSpider
Registry NumbersSources
Beilstein:901640Beilstein
CAS:2622-30-2ChemIDplus
CAS:2622-30-2NIST Chemistry WebBook
Citations