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CHEBI:5119 - fluoxetine hydrochloride
| ChEBI ID | CHEBI:5119 |
| ChEBI Name | fluoxetine hydrochloride |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder. |
| Last Modified | 20 July 2015 |
| Formula | C17H19ClF3NO |
| Net Charge | 0 |
| Average Mass | 345.787 |
| Monoisotopic Mass | 345.11073 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. |
| Applications: | antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| fluoxetine hydrochloride (CHEBI:5119) has part (R)-fluoxetine hydrochloride (CHEBI:86996) |
| fluoxetine hydrochloride (CHEBI:5119) has part (S)-fluoxetine hydrochloride (CHEBI:86997) |
| fluoxetine hydrochloride (CHEBI:5119) has role analgesic (CHEBI:35480) |
| fluoxetine hydrochloride (CHEBI:5119) has role antidepressant (CHEBI:35469) |
| fluoxetine hydrochloride (CHEBI:5119) has role serotonin uptake inhibitor (CHEBI:50949) |
| fluoxetine hydrochloride (CHEBI:5119) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride |
| Synonyms | Source |
|---|---|
| rac-fluoxetine hydrochloride | ChEBI |
| (±)-fluoxetine hydrochloride | ChEBI |
| (±)-fluoxetine HCl | ChEBI |
| (±)-methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride | ChemIDplus |
| 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride | ChemIDplus |
| (±)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride | ChemIDplus |
| Brand Names | Source |
|---|---|
| Prozac | KEGG DRUG |
| Margrilan | ChemIDplus |
| Fluoxac | ChemIDplus |
| Ansilan | ChemIDplus |
| Oxedep | ChemIDplus |
| Proctin | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| D00823 | KEGG DRUG |
| DB00472 | DrugBank |
| Fluoxetine | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:6759273 | Reaxys |
| Reaxys:27994391 | Reaxys |
| CAS:59333-67-4 | KEGG DRUG |
| CAS:56296-78-7 | ChemIDplus |
| Citations |
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