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CHEBI:51137 - mianserin
| Formula | C18H20N2 |
| Net Charge | 0 |
| Average Mass | 264.372 |
| Monoisotopic Mass | 264.16265 |
| SMILES | CN1CCN2c3ccccc3Cc3ccccc3C2C1 |
| InChI | InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 |
| InChIKey | UEQUQVLFIPOEMF-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. histamine agonist A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). |
| Applications: | sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. histamine agonist A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| mianserin (CHEBI:51137) has role adrenergic uptake inhibitor (CHEBI:35640) |
| mianserin (CHEBI:51137) has role antidepressant (CHEBI:35469) |
| mianserin (CHEBI:51137) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| mianserin (CHEBI:51137) has role geroprotector (CHEBI:176497) |
| mianserin (CHEBI:51137) has role H1-receptor antagonist (CHEBI:37955) |
| mianserin (CHEBI:51137) has role histamine agonist (CHEBI:35678) |
| mianserin (CHEBI:51137) has role sedative (CHEBI:35717) |
| mianserin (CHEBI:51137) has role serotonergic antagonist (CHEBI:48279) |
| mianserin (CHEBI:51137) has role α-adrenergic antagonist (CHEBI:37890) |
| mianserin (CHEBI:51137) is a dibenzoazepine (CHEBI:47804) |
| Incoming Relation(s) |
| mianserin hydrochloride (CHEBI:31843) has part mianserin (CHEBI:51137) |
| IUPAC Name |
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| 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine |
| INNs | Source |
|---|---|
| mianserin | WHO MedNet |
| mianserina | WHO MedNet |
| miansérine | WHO MedNet |
| mianserinum | WHO MedNet |
| Synonym | Source |
|---|---|
| 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine | ChemIDplus |
| Citations |
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