EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:5102 - fludrocortisone acetate

Default Structure
ChEBI IDCHEBI:5102
ChEBI Namefludrocortisone acetate
Stars
DefinitionAn acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
Last Modified7 February 2018
DownloadsMolfile
FormulaC23H31FO6
Net Charge0
Average Mass422.493
Monoisotopic Mass422.21047
SMILES[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@@]21C
InChIInChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
InChIKeySYWHXTATXSMDSB-GSLJADNHSA-N
Roles Classification
Biological Roles:
antiviral agent  A substance that destroys or inhibits replication of viruses.
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antiparkinson drug  A drug used in the treatment of Parkinson's disease.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
fludrocortisone acetate (CHEBI:5102) has functional parent fludrocortisone (CHEBI:50885)
fludrocortisone acetate (CHEBI:5102) has role antidepressant (CHEBI:35469)
fludrocortisone acetate (CHEBI:5102) has role antineoplastic agent (CHEBI:35610)
fludrocortisone acetate (CHEBI:5102) has role antiparkinson drug (CHEBI:48407)
fludrocortisone acetate (CHEBI:5102) has role antiviral agent (CHEBI:22587)
fludrocortisone acetate (CHEBI:5102) is a 11β-hydroxy steroid (CHEBI:35346)
fludrocortisone acetate (CHEBI:5102) is a 17α-hydroxy steroid (CHEBI:35342)
fludrocortisone acetate (CHEBI:5102) is a 20-oxo steroid (CHEBI:36885)
fludrocortisone acetate (CHEBI:5102) is a 3-oxo-Δ4 steroid (CHEBI:47909)
fludrocortisone acetate (CHEBI:5102) is a acetate ester (CHEBI:47622)
fludrocortisone acetate (CHEBI:5102) is a fluorinated steroid (CHEBI:50830)
fludrocortisone acetate (CHEBI:5102) is a mineralocorticoid (CHEBI:25354)
fludrocortisone acetate (CHEBI:5102) is a tertiary α-hydroxy ketone (CHEBI:139592)
IUPAC Name 
9-fluoro-11β,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
Synonyms  Source
(11β)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetateIUPAC
9α-fluorohydrocortisone 21-acetateChemIDplus
9α-fluorohydrocortisone acetateChemIDplus
fludrocortisone 21-acetateChemIDplus
Fludrocortisoni acetasChEMBL
fluohydrocortisone acetateChemIDplus
Brand Names  Source
AlfloroneChEBI
Alflorone acetateChemIDplus
AstoninChEMBL
Cortef-FChemIDplus
CortineffChemIDplus
F-CortefChEBI
Manual XrefsDatabases
1191DrugCentral
C08186KEGG COMPOUND
D00986KEGG DRUG
US2957013Patent
Registry NumbersSources
Reaxys:3019450Reaxys
CAS:514-36-3ChemIDplus
CAS:514-36-3KEGG COMPOUND
Citations