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CHEBI:50693 - milrinone

ChEBI IDCHEBI:50693
ChEBI Namemilrinone
Stars
DefinitionA member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Secondary ChEBI IDsCHEBI:6938, CHEBI:44019
Last Modified14 May 2024
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC12H9N3O
Net Charge0
Average Mass211.224
Monoisotopic Mass211.07456
SMILESCc1nc(=O)c(C#N)cc1-c1ccncc1
InChIInChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChIKeyPZRHRDRVRGEVNW-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor  An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Applications:
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
vasodilator agent  A drug used to cause dilation of the blood vessels.
cardiotonic drug  A drug that has a strengthening effect on the heart or that can increase cardiac output.
ChEBI Ontology
Outgoing Relation(s)
milrinone (CHEBI:50693) has role cardiotonic drug (CHEBI:38147)
milrinone (CHEBI:50693) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
milrinone (CHEBI:50693) has role platelet aggregation inhibitor (CHEBI:50427)
milrinone (CHEBI:50693) has role vasodilator agent (CHEBI:35620)
milrinone (CHEBI:50693) is a bipyridines (CHEBI:50511)
milrinone (CHEBI:50693) is a nitrile (CHEBI:18379)
milrinone (CHEBI:50693) is a pyridone (CHEBI:38183)
Incoming Relation(s)
milrinone lactate (CHEBI:34850) has part milrinone (CHEBI:50693)
IUPAC Name 
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
INNs  Source
milrinoneChemIDplus
milrinonaChemIDplus
milrinonumChemIDplus
milrinoneWHO MedNet
Synonyms  Source
MilrinoneKEGG COMPOUND
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrileChemIDplus
Manual XrefsDatabases
C07224KEGG COMPOUND
MILPDBeChem
D00417KEGG DRUG
DB00235DrugBank
BE886336Patent
US4313951Patent
US4413127Patent
MilrinoneWikipedia
HMDB0014380HMDB
LSM-3493LINCS
1809DrugCentral
Registry NumbersSources
Beilstein:3546821Beilstein
Reaxys:3546821Reaxys
CAS:78415-72-2ChemIDplus
Citations