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CHEBI:50693 - milrinone

Default Structure
ChEBI IDCHEBI:50693
ChEBI Namemilrinone
Stars
DefinitionA member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Secondary ChEBI IDsCHEBI:6938, CHEBI:44019
Last Modified14 May 2024
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC12H9N3O
Net Charge0
Average Mass211.224
Monoisotopic Mass211.07456
SMILESCc1nc(=O)c(C#N)cc1-c1ccncc1
InChIInChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChIKeyPZRHRDRVRGEVNW-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor  An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Applications:
vasodilator agent  A drug used to cause dilation of the blood vessels.
cardiotonic drug  A drug that has a strengthening effect on the heart or that can increase cardiac output.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
antispasmodic drug  A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
ChEBI Ontology
Outgoing Relation(s)
milrinone (CHEBI:50693) has role antihypertensive agent (CHEBI:35674)
milrinone (CHEBI:50693) has role antispasmodic drug (CHEBI:53784)
milrinone (CHEBI:50693) has role cardiotonic drug (CHEBI:38147)
milrinone (CHEBI:50693) has role cardiovascular drug (CHEBI:35554)
milrinone (CHEBI:50693) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
milrinone (CHEBI:50693) has role platelet aggregation inhibitor (CHEBI:50427)
milrinone (CHEBI:50693) has role vasodilator agent (CHEBI:35620)
milrinone (CHEBI:50693) is a bipyridines (CHEBI:50511)
milrinone (CHEBI:50693) is a nitrile (CHEBI:18379)
milrinone (CHEBI:50693) is a pyridone (CHEBI:38183)
Incoming Relation(s)
milrinone lactate (CHEBI:34850) has part milrinone (CHEBI:50693)
IUPAC Name 
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
INNs  Source
milrinonaChemIDplus
milrinoneWHO MedNet
milrinoneChemIDplus
milrinonumChemIDplus
Synonyms  Source
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrileChemIDplus
MilrilaChEMBL
MilrinoneKEGG COMPOUND
NSC-760072ChEMBL
WIN 47,203-2ChEMBL
WIN-47203-2ChEMBL
Manual XrefsDatabases
1809DrugCentral
BE886336Patent
C07224KEGG COMPOUND
D00417KEGG DRUG
DB00235DrugBank
HMDB0014380HMDB
LSM-3493LINCS
MILPDBeChem
MilrinoneWikipedia
US4313951Patent
US4413127Patent
Registry NumbersSources
Beilstein:3546821Beilstein
Reaxys:3546821Reaxys
CAS:78415-72-2ChemIDplus
Citations