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CHEBI:4887 - ethosuximide

ChEBI IDCHEBI:4887
ChEBI Nameethosuximide
Stars
DefinitionA dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Secondary ChEBI IDCHEBI:131811
Last Modified7 February 2023
DownloadsMolfile
FormulaC7H11NO2
Net Charge0
Average Mass141.170
Monoisotopic Mass141.07898
SMILESCCC1(C)CC(=O)NC1=O
InChIInChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChIKeyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
T-type calcium channel blocker  Any agent that interferes with the activity of T-type calcium channels.
Applications:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
anticonvulsant  A drug used to prevent seizures or reduce their severity.
ChEBI Ontology
Outgoing Relation(s)
ethosuximide (CHEBI:4887) has role anticonvulsant (CHEBI:35623)
ethosuximide (CHEBI:4887) has role geroprotector (CHEBI:176497)
ethosuximide (CHEBI:4887) has role T-type calcium channel blocker (CHEBI:194338)
ethosuximide (CHEBI:4887) is a dicarboximide (CHEBI:35356)
ethosuximide (CHEBI:4887) is a pyrrolidinone (CHEBI:38275)
Incoming Relation(s)
(R)-ethosuximide (CHEBI:60354) is a ethosuximide (CHEBI:4887)
(S)-ethosuximide (CHEBI:60355) is a ethosuximide (CHEBI:4887)
IUPAC Name 
3-ethyl-3-methylpyrrolidine-2,5-dione
INNs  Source
ethosuximideChemIDplus
etosuximidaChemIDplus
ethosuximidumChemIDplus
éthosuximideWHO MedNet
Synonyms  Source
EthosuximideKEGG COMPOUND
γ-methyl-γ-ethyl-succinimideChemIDplus
(±)-2-ethyl-2-methylsuccinimideChemIDplus
3-methyl-3-ethylsuccinimideChemIDplus
2-ethyl-2-methylsuccinimideChemIDplus
3-methyl-3-ethylpyrrolidine-2,5-dioneChemIDplus
Manual XrefsDatabases
C07505KEGG COMPOUND
D00539KEGG DRUG
DB00593DrugBank
EthosuximideWikipedia
HMDB0014731HMDB
LSM-5195LINCS
1087DrugCentral
3175ChemSpider
Registry NumbersSources
Reaxys:117054Reaxys
CAS:77-67-8KEGG COMPOUND
CAS:77-67-8ChemIDplus
CAS:77-67-8NIST Chemistry WebBook
Citations