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CHEBI:4858 - estazolam

ChEBI IDCHEBI:4858
ChEBI Nameestazolam
Stars
DefinitionA triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.
Secondary ChEBI IDCHEBI:149847
Last Modified22 February 2017
DownloadsMolfile
FormulaC16H11ClN4
Net Charge0
Average Mass294.745
Monoisotopic Mass294.06722
SMILESClc1ccc2c(c1)C(c1ccccc1)=NCc1nncn1-2
InChIInChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
InChIKeyCDCHDCWJMGXXRH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Applications:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
anticonvulsant  A drug used to prevent seizures or reduce their severity.
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
estazolam (CHEBI:4858) has role anticonvulsant (CHEBI:35623)
estazolam (CHEBI:4858) has role anxiolytic drug (CHEBI:35474)
estazolam (CHEBI:4858) has role GABA modulator (CHEBI:50268)
estazolam (CHEBI:4858) is a triazoles (CHEBI:35727)
estazolam (CHEBI:4858) is a triazolobenzodiazepine (CHEBI:35501)
IUPAC Name 
8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
INNs  Source
estazolamumChemIDplus
estazolamChemIDplus
Synonym  Source
8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepineChemIDplus
Manual XrefsDatabases
D00311KEGG DRUG
DB01215DrugBank
DE2012190Patent
US3701782Patent
DE1955349Patent
DE2114441Patent
EstazolamWikipedia
1056DrugCentral
Registry NumbersSources
Beilstein:1220868Beilstein
CAS:29975-16-4KEGG DRUG
CAS:29975-16-4ChemIDplus
CAS:29975-16-4NIST Chemistry WebBook
Citations