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CHEBI:47781 - desipramine
| Formula | C18H22N2 |
| Net Charge | 0 |
| Average Mass | 266.388 |
| Monoisotopic Mass | 266.17830 |
| SMILES | CNCCCN1c2ccccc2CCc2ccccc21 |
| InChI | InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 |
| InChIKey | HCYAFALTSJYZDH-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | drug allergen Any drug which causes the onset of an allergic reaction. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of sphingomyelin phosphodiesterase (EC 3.1.4.12). EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). |
| Applications: | drug allergen Any drug which causes the onset of an allergic reaction. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| desipramine (CHEBI:47781) has role adrenergic uptake inhibitor (CHEBI:35640) |
| desipramine (CHEBI:47781) has role antidepressant (CHEBI:35469) |
| desipramine (CHEBI:47781) has role cholinergic antagonist (CHEBI:48873) |
| desipramine (CHEBI:47781) has role drug allergen (CHEBI:88188) |
| desipramine (CHEBI:47781) has role EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor (CHEBI:76811) |
| desipramine (CHEBI:47781) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| desipramine (CHEBI:47781) has role H1-receptor antagonist (CHEBI:37955) |
| desipramine (CHEBI:47781) has role serotonin uptake inhibitor (CHEBI:50949) |
| desipramine (CHEBI:47781) has role α-adrenergic antagonist (CHEBI:37890) |
| desipramine (CHEBI:47781) is a dibenzoazepine (CHEBI:47804) |
| desipramine (CHEBI:47781) is a secondary amino compound (CHEBI:50995) |
| Incoming Relation(s) |
| desipramine hydrochloride (CHEBI:4449) has part desipramine (CHEBI:47781) |
| IUPAC Name |
|---|
| 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine |
| INNs | Source |
|---|---|
| desipraminum | ChEBI |
| desipramine | ChEBI |
| desipramina | ChEBI |
| désipramine | ChEBI |
| Synonyms | Source |
|---|---|
| Desipramine | KEGG COMPOUND |
| 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE | PDBeChem |
| DMI | ChemIDplus |
| demethylimipramine | ChemIDplus |
| desmethylimipramine | NIST Chemistry WebBook |
| monodemethylimipramine | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| C06943 | KEGG COMPOUND |
| DSM | PDBeChem |
| DB01151 | DrugBank |
| D07791 | KEGG DRUG |
| Desipramine | Wikipedia |
| HMDB0015282 | HMDB |
| LSM-3351 | LINCS |
| 812 | DrugCentral |
| Citations |
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