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CHEBI:4707 - doxacurium chloride
| ChEBI ID | CHEBI:4707 |
| ChEBI Name | doxacurium chloride |
| Stars | |
| Definition | The dichloride salt of doxacurium. It is a mixture of the (1R,2S,1'S,2'R), (1R,2S,1'R,2'S) and (1S,2R,1'S,2'R) stereoisomers (a meso isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride, all of which are in a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, it is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care. |
| Last Modified | 10 August 2010 |
| Formula | C56H78Cl2N2O16 |
| Net Charge | 0 |
| Average Mass | 1106.130 |
| Monoisotopic Mass | 1104.47284 |
| Roles Classification |
|---|
| Application: | muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| doxacurium chloride (CHEBI:4707) has part (1R,2S,1'R,2'S)-doxacurium chloride (CHEBI:59821) |
| doxacurium chloride (CHEBI:4707) has part (1S,2R,1'S,2'R)-doxacurium chloride (CHEBI:59823) |
| doxacurium chloride (CHEBI:4707) has part meso-doxacurium chloride (CHEBI:59819) |
| doxacurium chloride (CHEBI:4707) has part doxacurium (CHEBI:4706) |
| doxacurium chloride (CHEBI:4707) has role muscle relaxant (CHEBI:51371) |
| doxacurium chloride (CHEBI:4707) is a chloride salt (CHEBI:23114) |
| doxacurium chloride (CHEBI:4707) is a diester (CHEBI:51307) |
| doxacurium chloride (CHEBI:4707) is a quaternary ammonium salt (CHEBI:35273) |
| INNs | Source |
|---|---|
| cloruro de doxacurio | ChemIDplus |
| chlorure de doxacurium | ChemIDplus |
| doxacurii chloridum | ChemIDplus |
| doxacurium chloride | ChemIDplus |
| Synonym | Source |
|---|---|
| (1R,2S;1S,2R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1), mixture with (±)-(1R*,2S*;1R*,2S*)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1) | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Beilstein:9184298 | Beilstein |
| Beilstein:9689361 | Beilstein |
| CAS:106819-53-8 | KEGG DRUG |
| CAS:106819-53-8 | ChemIDplus |