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CHEBI:3762 - dipotassium clorazepate

Default Structure
ChEBI IDCHEBI:3762
ChEBI Namedipotassium clorazepate
Stars
DefinitionThe compound of monopotassium clorazepate with potassium hydroxide. It is used for the management of anxiety disorders, for the short-term relief of anxiety, as adjunctive therapy in the management of epilepsy, and for the symptomatic relief of acute alcohol withdrawal.
Last Modified8 June 2010
DownloadsMolfile
FormulaC16H10ClN2O3.HO.2K
Net Charge0
Average Mass408.923
Monoisotopic Mass407.96815
SMILESO=C([O-])C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O.[K+].[K+].[OH-]
InChIInChI=1S/C16H11ClN2O3.2K.H2O/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12;;;/h1-8,14H,(H,18,20)(H,21,22);;;1H2/q;2*+1;/p-2
InChIKeyQCHSEDTUUKDTIG-UHFFFAOYSA-L
Roles Classification
Biological Role:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Applications:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
anticonvulsant  A drug used to prevent seizures or reduce their severity.
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
dipotassium clorazepate (CHEBI:3762) has part clorazepate monopotassium (CHEBI:59591)
dipotassium clorazepate (CHEBI:3762) has role anticonvulsant (CHEBI:35623)
dipotassium clorazepate (CHEBI:3762) has role anxiolytic drug (CHEBI:35474)
dipotassium clorazepate (CHEBI:3762) has role GABA modulator (CHEBI:50268)
dipotassium clorazepate (CHEBI:3762) has role prodrug (CHEBI:50266)
dipotassium clorazepate (CHEBI:3762) is a potassium salt (CHEBI:26218)
IUPAC Name 
dipotassium 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate hydroxide
INNs  Source
clorazepate dipotassiqueChemIDplus
clorazepato dipotasicoChemIDplus
dikalii clorazepasChemIDplus
dipotassium clorazepateChEBI
Synonyms  Source
bipotassium chlorazepateChemIDplus
Clorazepate dipotassiumKEGG DRUG
Manual XrefsDatabases
D00694KEGG DRUG
DB00628DrugBank
Registry NumbersSources
Beilstein:9747917Beilstein
CAS:57109-90-7KEGG DRUG
CAS:57109-90-7ChemIDplus