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CHEBI:32246 - tolvaptan
| ChEBI ID | CHEBI:32246 |
| ChEBI Name | tolvaptan |
| Stars | |
| Definition | A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. |
| Last Modified | 15 May 2024 |
| Formula | C26H25ClN2O3 |
| Net Charge | 0 |
| Average Mass | 448.950 |
| Monoisotopic Mass | 448.15537 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | vasopressin receptor antagonist Any drug which blocks vasopressin receptors. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. renoprotective agent Any compound that is able to prevent damage to the kidneys. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. hepatoprotective agent Any compound that is able to prevent damage to the liver. vasopressin receptor antagonist Any drug which blocks vasopressin receptors. aquaretic A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss). |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tolvaptan (CHEBI:32246) has part (R)-tolvaptan (CHEBI:231426) |
| tolvaptan (CHEBI:32246) has part (S)-tolvaptan (CHEBI:231424) |
| tolvaptan (CHEBI:32246) has role antineoplastic agent (CHEBI:35610) |
| tolvaptan (CHEBI:32246) has role aquaretic (CHEBI:194423) |
| tolvaptan (CHEBI:32246) has role cardiovascular drug (CHEBI:35554) |
| tolvaptan (CHEBI:32246) has role hepatoprotective agent (CHEBI:62868) |
| tolvaptan (CHEBI:32246) has role renoprotective agent (CHEBI:231911) |
| tolvaptan (CHEBI:32246) has role vasopressin receptor antagonist (CHEBI:59680) |
| tolvaptan (CHEBI:32246) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| DM-4103 (CHEBI:183655) has functional parent tolvaptan (CHEBI:32246) |
| DM-4107 (CHEBI:183656) has functional parent tolvaptan (CHEBI:32246) |
| IUPAC Name |
|---|
| rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide |
| INNs | Source |
|---|---|
| tolvaptan | WHO MedNet |
| tolvaptan | WHO MedNet |
| tolvaptán | WHO MedNet |
| tolvaptanum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (±)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide | ChEBI |
| N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide | IUPAC |
| (RS)-tolvaptan | ChEBI |
| RS-tolvaptan | ChEBI |
| OPC 41061 | DrugCentral |
| OPC-41061 | DrugCentral |
| Brand Names | Source |
|---|---|
| Jinarc | DrugBank |
| Jynarque | DrugBank |
| Samsca | KEGG DRUG |
| Tolvaptan accord | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| CAS:150683-30-0 | KEGG COMPOUND |
| CAS:150683-30-0 | ChemIDplus |
| Citations |
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