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CHEBI:32246 - tolvaptan
| ChEBI ID | CHEBI:32246 |
| ChEBI Name | tolvaptan |
| Stars | |
| Definition | A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. |
| Last Modified | 15 May 2024 |
| Formula | C26H25ClN2O3 |
| Net Charge | 0 |
| Average Mass | 448.950 |
| Monoisotopic Mass | 448.15537 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | vasopressin receptor antagonist Any drug which blocks vasopressin receptors. |
| Applications: | aquaretic A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss). vasopressin receptor antagonist Any drug which blocks vasopressin receptors. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tolvaptan (CHEBI:32246) has part (R)-tolvaptan (CHEBI:231426) |
| tolvaptan (CHEBI:32246) has part (S)-tolvaptan (CHEBI:231424) |
| tolvaptan (CHEBI:32246) has role aquaretic (CHEBI:194423) |
| tolvaptan (CHEBI:32246) has role vasopressin receptor antagonist (CHEBI:59680) |
| tolvaptan (CHEBI:32246) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| DM-4103 (CHEBI:183655) has functional parent tolvaptan (CHEBI:32246) |
| DM-4107 (CHEBI:183656) has functional parent tolvaptan (CHEBI:32246) |
| IUPAC Name |
|---|
| rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide |
| INNs | Source |
|---|---|
| tolvaptan | WHO MedNet |
| tolvaptan | WHO MedNet |
| tolvaptán | WHO MedNet |
| tolvaptanum | WHO MedNet |
| Synonyms | Source |
|---|---|
| OPC 41061 | DrugCentral |
| OPC-41061 | DrugCentral |
| N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide | IUPAC |
| (±)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide | ChEBI |
| (RS)-tolvaptan | ChEBI |
| RS-tolvaptan | ChEBI |
| Brand Names | Source |
|---|---|
| Jinarc | DrugBank |
| Samsca | KEGG DRUG |
| Jynarque | DrugBank |
| Registry Numbers | Sources |
|---|---|
| CAS:150683-30-0 | KEGG COMPOUND |
| CAS:150683-30-0 | ChemIDplus |
| Citations |
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