EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:31847 - midodrine hydrochloride

ChEBI IDCHEBI:31847
ChEBI Namemidodrine hydrochloride
Stars
DefinitionA hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective α-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Last Modified19 April 2013
DownloadsMolfile
FormulaC12H18N2O4.HCl
Net Charge0
Average Mass290.747
Monoisotopic Mass290.10333
SMILESCOc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl
InChIInChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
InChIKeyMGCQZNBCJBRZDT-UHFFFAOYSA-N
Roles Classification
Biological Roles:
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
alpha-adrenergic agonist  An agent that selectively binds to and activates α-adrenergic receptors.
Applications:
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
vasoconstrictor agent  Drug used to cause constriction of the blood vessels.
alpha-adrenergic agonist  An agent that selectively binds to and activates α-adrenergic receptors.
ChEBI Ontology
Outgoing Relation(s)
midodrine hydrochloride (CHEBI:31847) has part midodrine(1+) (CHEBI:73243)
midodrine hydrochloride (CHEBI:31847) has role sympathomimetic agent (CHEBI:35524)
midodrine hydrochloride (CHEBI:31847) has role vasoconstrictor agent (CHEBI:50514)
midodrine hydrochloride (CHEBI:31847) has role α-adrenergic agonist (CHEBI:35569)
midodrine hydrochloride (CHEBI:31847) is a hydrochloride (CHEBI:36807)
IUPAC Name 
rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide hydrochloride
Synonyms  Source
(+-)-1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochlorideChemIDplus
(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochlorideChemIDplus
(+-)-Midodrine hydrochlorideChemIDplus
Midodrine HClChemIDplus
Brand Names  Source
Pro-AmatineKEGG DRUG
ProAmatineChEBI
Manual XrefsDatabases
D01307KEGG DRUG
DB00211DrugBank
WO2004018409Patent
HMDB0014356HMDB
Registry NumbersSources
Reaxys:6579688Reaxys
CAS:3092-17-9ChemIDplus
CAS:3092-17-9KEGG DRUG
Citations