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CHEBI:31625 - fluorometholone

ChEBI IDCHEBI:31625
ChEBI Namefluorometholone
Stars
DefinitionA member of the class of glucocorticoids that is Δ1-progesterone substituted at positions 11β and 17 by hydroxy groups, at position 6α by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Last Modified7 February 2018
DownloadsMolfile
FormulaC22H29FO4
Net Charge0
Average Mass376.468
Monoisotopic Mass376.20499
SMILES[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@@]21C
InChIInChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
InChIKeyFAOZLTXFLGPHNG-KNAQIMQKSA-N
Wikipedia
Roles Classification
Biological Role:
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Application:
anti-inflammatory drug  A substance that reduces or suppresses inflammation.
ChEBI Ontology
Outgoing Relation(s)
fluorometholone (CHEBI:31625) has functional parent Δ1-progesterone (CHEBI:34073)
fluorometholone (CHEBI:31625) has role anti-inflammatory drug (CHEBI:35472)
fluorometholone (CHEBI:31625) is a 11β-hydroxy steroid (CHEBI:35346)
fluorometholone (CHEBI:31625) is a 17α-hydroxy steroid (CHEBI:35342)
fluorometholone (CHEBI:31625) is a 20-oxo steroid (CHEBI:36885)
fluorometholone (CHEBI:31625) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
fluorometholone (CHEBI:31625) is a fluorinated steroid (CHEBI:50830)
fluorometholone (CHEBI:31625) is a glucocorticoid (CHEBI:24261)
fluorometholone (CHEBI:31625) is a tertiary α-hydroxy ketone (CHEBI:139592)
Incoming Relation(s)
fluorometholone acetate (CHEBI:78354) has functional parent fluorometholone (CHEBI:31625)
IUPAC Names 
(6α,11β)-9-fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione
INNs  Source
fluorometholoneKEGG DRUG
fluorométholoneDrugBank
fluorometolonaDrugBank
fluorometholonumDrugBank
Synonyms  Source
NSC 33001KEGG DRUG
FluorometholonDrugBank
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dioneChemIDplus
Brand Names  Source
Fluor-opKEGG DRUG
OxyloneKEGG DRUG
Manual XrefsDatabases
D01367KEGG DRUG
DB00324DrugBank
HMDB0014469HMDB
FluorometholoneWikipedia
1208DrugCentral
Registry NumbersSources
Reaxys:3172388Reaxys
CAS:426-13-1KEGG DRUG
CAS:426-13-1ChemIDplus
Citations