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CHEBI:31515 - domperidone

ChEBI IDCHEBI:31515
ChEBI Namedomperidone
Stars
Definition1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Secondary ChEBI IDCHEBI:464745
Last Modified22 February 2017
DownloadsMolfile

FormulaC22H24ClN5O2
Net Charge0
Average Mass425.920
Monoisotopic Mass425.16185
SMILESO=c1nc2ccccc2n1CCCN1CCC(n2c(=O)nc3cc(Cl)ccc32)CC1
InChIInChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
InChIKeyFGXWKSZFVQUSTL-UHFFFAOYSA-N

Roles Classification

ChEBI Ontology
IUPAC Name 
5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
INNs  Source
domperidonum  laChemIDplus
domperidoneChemIDplus
domperidona  esChemIDplus
Synonyms  Source
5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-oneChEMBL
1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-oneChEMBL
5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-oneChEMBL
5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinoneChemIDplus
Manual XrefsDatabases
D01745KEGG DRUG
DE2632870Patent
US4066772Patent
DB01184DrugBank
LSM-2850LINCS
945DrugCentral
Registry NumbersSources
Beilstein:903774Beilstein
CAS:57808-66-9KEGG DRUG
CAS:57808-66-9ChemIDplus