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CHEBI:31515 - domperidone
| Formula | C22H24ClN5O2 |
| Net Charge | 0 |
| Average Mass | 425.920 |
| Monoisotopic Mass | 425.16185 |
| SMILES | O=c1nc2ccccc2n1CCCN1CCC(n2c(=O)nc3cc(Cl)ccc32)CC1 |
| InChI | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| InChIKey | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Role: | dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. |
| Applications: | antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| domperidone (CHEBI:31515) has role antiemetic (CHEBI:50919) |
| domperidone (CHEBI:31515) has role dopaminergic antagonist (CHEBI:48561) |
| domperidone (CHEBI:31515) is a benzimidazoles (CHEBI:22715) |
| domperidone (CHEBI:31515) is a heteroarylpiperidine (CHEBI:48585) |
| Incoming Relation(s) |
| domperidone maleate (CHEBI:59812) has part domperidone (CHEBI:31515) |
| IUPAC Name |
|---|
| 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one |
| INNs | Source |
|---|---|
| domperidona | ChemIDplus |
| domperidone | ChemIDplus |
| domperidonum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one | ChEMBL |
| 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone | ChemIDplus |
| 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | ChEMBL |
| 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one | ChEMBL |