EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:31515 - domperidone
| Formula | C22H24ClN5O2 |
| Net Charge | 0 |
| Average Mass | 425.920 |
| Monoisotopic Mass | 425.16185 |
| SMILES | O=c1nc2ccccc2n1CCCN1CCC(n2c(=O)nc3cc(Cl)ccc32)CC1 |
| InChI | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| InChIKey | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| Applications: | antidiarrhoeal drug Any drug found useful in the symptomatic treatment of diarrhoea. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antiparkinson drug A drug used in the treatment of Parkinson's disease. gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| domperidone (CHEBI:31515) has role antidiarrhoeal drug (CHEBI:55323) |
| domperidone (CHEBI:31515) has role antiemetic (CHEBI:50919) |
| domperidone (CHEBI:31515) has role antiparkinson drug (CHEBI:48407) |
| domperidone (CHEBI:31515) has role dopaminergic antagonist (CHEBI:48561) |
| domperidone (CHEBI:31515) has role gastrointestinal drug (CHEBI:55324) |
| domperidone (CHEBI:31515) has role immunosuppressive agent (CHEBI:35705) |
| domperidone (CHEBI:31515) is a benzimidazoles (CHEBI:22715) |
| domperidone (CHEBI:31515) is a heteroarylpiperidine (CHEBI:48585) |
| domperidone (CHEBI:31515) is a organic molecular entity (CHEBI:50860) |
| Incoming Relation(s) |
| domperidone maleate (CHEBI:59812) has part domperidone (CHEBI:31515) |
| IUPAC Name |
|---|
| 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one |
| INNs | Source |
|---|---|
| domperidona | ChemIDplus |
| domperidone | ChemIDplus |
| domperidonum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one | ChEMBL |
| 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone | ChemIDplus |
| 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | ChEMBL |
| 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one | ChEMBL |
| NSC-299589 | ChEMBL |
| NSC-759575 | ChEMBL |
| Brand Names | Source |
|---|---|
| Domilium | ChEMBL |
| Evoxin | ChEMBL |
| Motilium 10 | ChEMBL |
| Motilium instants | ChEMBL |
| Vivadone | ChEMBL |
| Citations |
|---|