clobetasol propionate (CHEBI:31414)

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CHEBI:31414 - clobetasol propionate

ChEBI ID	CHEBI:31414
ChEBI Name	clobetasol propionate
Stars
Definition	The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Secondary ChEBI IDs	CHEBI:205078, CHEBI:282070
Last Modified	22 February 2017
Downloads	Molfile

Formula	C25H32ClFO5
Net Charge	0
Average Mass	466.977
Monoisotopic Mass	466.19223
SMILES	[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@@]21C
InChI	InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
InChIKey	CBGUOGMQLZIXBE-XGQKBEPLSA-N

Wikipedia

Roles Classification

Biological Role:

hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.

Applications:

antirheumatic drug A drug used to treat rheumatoid arthritis.

dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin.

antipsoriatic A drug used to treat psoriasis.

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases.

anti-inflammatory drug A substance that reduces or suppresses inflammation.

ChEBI Ontology

Outgoing Relation(s)
	clobetasol propionate (CHEBI:31414) has functional parent clobetasol (CHEBI:205919)
	clobetasol propionate (CHEBI:31414) has functional parent propionic acid (CHEBI:30768)
	clobetasol propionate (CHEBI:31414) has role anti-inflammatory drug (CHEBI:35472)
	clobetasol propionate (CHEBI:31414) has role antineoplastic agent (CHEBI:35610)
	clobetasol propionate (CHEBI:31414) has role antipsoriatic (CHEBI:50748)
	clobetasol propionate (CHEBI:31414) has role antirheumatic drug (CHEBI:35842)
	clobetasol propionate (CHEBI:31414) has role dermatologic drug (CHEBI:50177)
	clobetasol propionate (CHEBI:31414) has role ophthalmology drug (CHEBI:66981)
	clobetasol propionate (CHEBI:31414) is a 11β-hydroxy steroid (CHEBI:35346)
	clobetasol propionate (CHEBI:31414) is a 20-oxo steroid (CHEBI:36885)
	clobetasol propionate (CHEBI:31414) is a 3-oxo-Δ¹,Δ⁴-steroid (CHEBI:77166)
	clobetasol propionate (CHEBI:31414) is a chlorinated steroid (CHEBI:77175)
	clobetasol propionate (CHEBI:31414) is a fluorinated steroid (CHEBI:50830)
	clobetasol propionate (CHEBI:31414) is a glucocorticoid (CHEBI:24261)

IUPAC Name
21-chloro-9-fluoro-11β-hydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate

Synonyms	Source
21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate	ChemIDplus
CCI 4725	ChEMBL
CCI-4725	ChEMBL
Clobecort amex	ChEMBL
clobetasol 17-propanoate	ChEBI
clobetasol 17-propionate	ChemIDplus

Brand Names	Source
Clarelux	ChEMBL
Clobaderm	ChEMBL
Clobetasol propionate (emollient)	ChEMBL
Clobex	ChEMBL
Cormax	ChEMBL
Dermovate	ChEMBL

Manual Xrefs	Databases
4452	DrugCentral
Clobetasol	Wikipedia
D01272	KEGG DRUG
DB01013	DrugBank

Registry Numbers	Sources
Beilstein:4769432	Beilstein
CAS:25122-46-7	ChemIDplus
CAS:25122-46-7	KEGG DRUG

Citations