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CHEBI:31262 - benserazide hydrochloride

ChEBI IDCHEBI:31262
ChEBI Namebenserazide hydrochloride
Stars
DefinitionA hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone.
Last Modified15 March 2012
DownloadsMolfile
FormulaC10H15N3O5.HCl
Net Charge0
Average Mass293.707
Monoisotopic Mass293.07785
SMILESCl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
InChIInChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChIKeyULFCBIUXQQYDEI-UHFFFAOYSA-N
Roles Classification
Biological Roles:
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor  An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of aromatic-L-amino-acid decarboxylase (EC 4.1.1.28).
dopaminergic agent  A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Applications:
antiparkinson drug  A drug used in the treatment of Parkinson's disease.
dopaminergic agent  A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
ChEBI Ontology
Outgoing Relation(s)
benserazide hydrochloride (CHEBI:31262) has part benserazide(1+) (CHEBI:64190)
benserazide hydrochloride (CHEBI:31262) has role antiparkinson drug (CHEBI:48407)
benserazide hydrochloride (CHEBI:31262) has role dopaminergic agent (CHEBI:48560)
benserazide hydrochloride (CHEBI:31262) has role EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor (CHEBI:59321)
benserazide hydrochloride (CHEBI:31262) is a hydrochloride (CHEBI:36807)
IUPAC Name 
2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
Synonyms  Source
3-hydroxy-1-oxo-1-[2-(2,3,4-trihydroxybenzyl)hydrazinyl]propan-2-aminium chlorideIUPAC
Ro 4-4602/001ChemIDplus
2'-(2,3,4-trihydroxybenzyl)-DL-serinohydrazide monohydrochlorideChemIDplus
benserazide HClChemIDplus
DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazine hydrochlorideChemIDplus
Manual XrefsDatabases
D01653KEGG DRUG
Registry NumbersSources
Reaxys:6494463Reaxys
CAS:14919-77-8KEGG DRUG
CAS:14919-77-8ChemIDplus