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CHEBI:2979 - baicalein
| Formula | C15H10O5 |
| Net Charge | 0 |
| Average Mass | 270.240 |
| Monoisotopic Mass | 270.05282 |
| SMILES | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 |
| InChI | InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H |
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Lepisorus ussuriensis (ncbitaxon:699700) | whole plant (BTO:0001461) | PubMed (26569039) |
| Roles Classification |
|---|
| Chemical Roles: | antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Biological Roles: | apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 12-lipoxygenase (EC 1.13.11.31). EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33). plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. EC 4.1.1.17 (ornithine decarboxylase) inhibitor An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of ornithine decarboxylase (EC 4.1.1.17). anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. hormone antagonist A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69). prostaglandin antagonist A compound that inhibits the action of prostaglandins. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. |
| Applications: | angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. hormone antagonist A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. anti-inflammatory agent Any compound that has anti-inflammatory effects. prostaglandin antagonist A compound that inhibits the action of prostaglandins. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| baicalein (CHEBI:2979) has role angiogenesis inhibitor (CHEBI:48422) |
| baicalein (CHEBI:2979) has role anti-inflammatory agent (CHEBI:67079) |
| baicalein (CHEBI:2979) has role antibacterial agent (CHEBI:33282) |
| baicalein (CHEBI:2979) has role anticoronaviral agent (CHEBI:149553) |
| baicalein (CHEBI:2979) has role antifungal agent (CHEBI:35718) |
| baicalein (CHEBI:2979) has role antineoplastic agent (CHEBI:35610) |
| baicalein (CHEBI:2979) has role antioxidant (CHEBI:22586) |
| baicalein (CHEBI:2979) has role apoptosis inducer (CHEBI:68495) |
| baicalein (CHEBI:2979) has role EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor (CHEBI:64995) |
| baicalein (CHEBI:2979) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996) |
| baicalein (CHEBI:2979) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| baicalein (CHEBI:2979) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285) |
| baicalein (CHEBI:2979) has role EC 4.1.1.17 (ornithine decarboxylase) inhibitor (CHEBI:139556) |
| baicalein (CHEBI:2979) has role ferroptosis inhibitor (CHEBI:173084) |
| baicalein (CHEBI:2979) has role geroprotector (CHEBI:176497) |
| baicalein (CHEBI:2979) has role hormone antagonist (CHEBI:49020) |
| baicalein (CHEBI:2979) has role plant metabolite (CHEBI:76924) |
| baicalein (CHEBI:2979) has role prostaglandin antagonist (CHEBI:49023) |
| baicalein (CHEBI:2979) has role radical scavenger (CHEBI:48578) |
| baicalein (CHEBI:2979) is a trihydroxyflavone (CHEBI:27116) |
| baicalein (CHEBI:2979) is conjugate acid of baicalein(1−) (CHEBI:78324) |
| Incoming Relation(s) |
| 5,6,7-trimethoxyflavone (CHEBI:2980) has functional parent baicalein (CHEBI:2979) |
| baicalin (CHEBI:2981) has functional parent baicalein (CHEBI:2979) |
| baicalein(1−) (CHEBI:78324) is conjugate base of baicalein (CHEBI:2979) |
| IUPAC Name |
|---|
| 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one |
| Synonyms | Source |
|---|---|
| 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one | IUPAC |
| 5,6,7-Trihydroxyflavone | KEGG COMPOUND |
| Baicalein | KEGG COMPOUND |
| Brand Name | Source |
|---|---|
| Noroxylin | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| 3WL | PDBeChem |
| 4444924 | ChemSpider |
| Baicalein | Wikipedia |
| C00001022 | KNApSAcK |
| C10023 | KEGG COMPOUND |
| CN102429899 | Patent |
| CPD-12724 | MetaCyc |
| DB16101 | DrugBank |
| FDB012057 | FooDB |
| HMDB0134890 | HMDB |
| LMPK12111095 | LIPID MAPS |
| LSM-6355 | LINCS |
| Registry Numbers | Sources |
|---|---|
| Reaxys:272683 | Reaxys |
| CAS:491-67-8 | KEGG COMPOUND |
| CAS:491-67-8 | ChemIDplus |
| Citations |
|---|