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CHEBI:2979 - baicalein
| Formula | C15H10O5 |
| Net Charge | 0 |
| Average Mass | 270.240 |
| Monoisotopic Mass | 270.05282 |
| SMILES | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 |
| InChI | InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H |
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Lepisorus ussuriensis (ncbitaxon:699700) | whole plant (BTO:0001461) | PubMed (26569039) |
| Roles Classification |
|---|
| Chemical Roles: | radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| Biological Roles: | antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 12-lipoxygenase (EC 1.13.11.31). prostaglandin antagonist A compound that inhibits the action of prostaglandins. EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33). anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. EC 4.1.1.17 (ornithine decarboxylase) inhibitor An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of ornithine decarboxylase (EC 4.1.1.17). EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). hormone antagonist A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| Applications: | angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. prostaglandin antagonist A compound that inhibits the action of prostaglandins. anti-inflammatory agent Any compound that has anti-inflammatory effects. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. hormone antagonist A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| baicalein (CHEBI:2979) has role angiogenesis inhibitor (CHEBI:48422) |
| baicalein (CHEBI:2979) has role anti-inflammatory agent (CHEBI:67079) |
| baicalein (CHEBI:2979) has role antibacterial agent (CHEBI:33282) |
| baicalein (CHEBI:2979) has role anticoronaviral agent (CHEBI:149553) |
| baicalein (CHEBI:2979) has role antifungal agent (CHEBI:35718) |
| baicalein (CHEBI:2979) has role antineoplastic agent (CHEBI:35610) |
| baicalein (CHEBI:2979) has role antioxidant (CHEBI:22586) |
| baicalein (CHEBI:2979) has role apoptosis inducer (CHEBI:68495) |
| baicalein (CHEBI:2979) has role EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor (CHEBI:64995) |
| baicalein (CHEBI:2979) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996) |
| baicalein (CHEBI:2979) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| baicalein (CHEBI:2979) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285) |
| baicalein (CHEBI:2979) has role EC 4.1.1.17 (ornithine decarboxylase) inhibitor (CHEBI:139556) |
| baicalein (CHEBI:2979) has role ferroptosis inhibitor (CHEBI:173084) |
| baicalein (CHEBI:2979) has role geroprotector (CHEBI:176497) |
| baicalein (CHEBI:2979) has role hormone antagonist (CHEBI:49020) |
| baicalein (CHEBI:2979) has role plant metabolite (CHEBI:76924) |
| baicalein (CHEBI:2979) has role prostaglandin antagonist (CHEBI:49023) |
| baicalein (CHEBI:2979) has role radical scavenger (CHEBI:48578) |
| baicalein (CHEBI:2979) is a trihydroxyflavone (CHEBI:27116) |
| baicalein (CHEBI:2979) is conjugate acid of baicalein(1−) (CHEBI:78324) |
| Incoming Relation(s) |
| 5,6,7-trimethoxyflavone (CHEBI:2980) has functional parent baicalein (CHEBI:2979) |
| baicalin (CHEBI:2981) has functional parent baicalein (CHEBI:2979) |
| baicalein(1−) (CHEBI:78324) is conjugate base of baicalein (CHEBI:2979) |
| IUPAC Name |
|---|
| 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one |
| Synonyms | Source |
|---|---|
| Baicalein | KEGG COMPOUND |
| 5,6,7-Trihydroxyflavone | KEGG COMPOUND |
| 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one | IUPAC |
| Brand Name | Source |
|---|---|
| Noroxylin | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| C10023 | KEGG COMPOUND |
| CPD-12724 | MetaCyc |
| LMPK12111095 | LIPID MAPS |
| Baicalein | Wikipedia |
| CN102429899 | Patent |
| C00001022 | KNApSAcK |
| LSM-6355 | LINCS |
| DB16101 | DrugBank |
| HMDB0134890 | HMDB |
| 4444924 | ChemSpider |
| FDB012057 | FooDB |
| 3WL | PDBeChem |
| Registry Numbers | Sources |
|---|---|
| Reaxys:272683 | Reaxys |
| CAS:491-67-8 | KEGG COMPOUND |
| CAS:491-67-8 | ChemIDplus |
| Citations |
|---|