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CHEBI:17026 - progesterone

Default Structure
ChEBI IDCHEBI:17026
ChEBI Nameprogesterone
Stars
DefinitionA C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Secondary ChEBI IDsCHEBI:439, CHEBI:8453, CHEBI:14896, CHEBI:18798, CHEBI:26269, CHEBI:28589, CHEBI:45786
Last Modified21 May 2026
DownloadsMolfile
FormulaC21H30O2
Net Charge0
Average Mass314.469
Monoisotopic Mass314.22458
SMILES[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H]
InChIInChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
Wikipedia
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) - DOI (10.1038/nbt.2488)
Mus musculus (ncbitaxon:10090) - PubMed (19425150) Source: BioModels - MODEL1507180067
Roles Classification
Biological Roles:
mouse metabolite  Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
progesterone receptor agonist  A hormone agonist that binds to and activates progesterone receptors.
progestin  A synthetic progestogen.
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
antiviral agent  A substance that destroys or inhibits replication of viruses.
anti-HIV agent  An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
contraceptive drug  A chemical substance that prevents or reduces the probability of conception.
bone density conservation agent  An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anticoagulant  An agent that prevents blood clotting.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
progesterone receptor agonist  A hormone agonist that binds to and activates progesterone receptors.
appetite enhancer  A drug which increases appetite.
anticonvulsant  A drug used to prevent seizures or reduce their severity.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
hypoglycemic agent  A drug which lowers the blood glucose level.
ChEBI Ontology
Outgoing Relation(s)
progesterone (CHEBI:17026) has parent hydride pregnane (CHEBI:8386)
progesterone (CHEBI:17026) has role anti-HIV agent (CHEBI:64946)
progesterone (CHEBI:17026) has role anticoagulant (CHEBI:50249)
progesterone (CHEBI:17026) has role anticonvulsant (CHEBI:35623)
progesterone (CHEBI:17026) has role antidepressant (CHEBI:35469)
progesterone (CHEBI:17026) has role antihypertensive agent (CHEBI:35674)
progesterone (CHEBI:17026) has role antineoplastic agent (CHEBI:35610)
progesterone (CHEBI:17026) has role antiviral agent (CHEBI:22587)
progesterone (CHEBI:17026) has role appetite enhancer (CHEBI:50779)
progesterone (CHEBI:17026) has role bone density conservation agent (CHEBI:50646)
progesterone (CHEBI:17026) has role cardiovascular drug (CHEBI:35554)
progesterone (CHEBI:17026) has role contraceptive drug (CHEBI:49323)
progesterone (CHEBI:17026) has role human metabolite (CHEBI:77746)
progesterone (CHEBI:17026) has role hypoglycemic agent (CHEBI:35526)
progesterone (CHEBI:17026) has role mouse metabolite (CHEBI:75771)
progesterone (CHEBI:17026) has role neuroprotective agent (CHEBI:63726)
progesterone (CHEBI:17026) has role progesterone receptor agonist (CHEBI:70709)
progesterone (CHEBI:17026) has role progestin (CHEBI:59826)
progesterone (CHEBI:17026) is a 20-oxo steroid (CHEBI:36885)
progesterone (CHEBI:17026) is a 3-oxo-Δ4 steroid (CHEBI:47909)
progesterone (CHEBI:17026) is a C21-steroid hormone (CHEBI:64600)
Incoming Relation(s)
11-deoxycorticosterone (CHEBI:16973) has functional parent progesterone (CHEBI:17026)
11,21-dioxoprogesterone (CHEBI:78601) has functional parent progesterone (CHEBI:17026)
11α-hydroxyprogesterone (CHEBI:16076) has functional parent progesterone (CHEBI:17026)
11β-hydroxyprogesterone (CHEBI:28247) has functional parent progesterone (CHEBI:17026)
12α-hydroxyprogesterone (CHEBI:34153) has functional parent progesterone (CHEBI:17026)
15β-hydroxyprogesterone (CHEBI:59418) has functional parent progesterone (CHEBI:17026)
16,17-didehydroprogesterone (CHEBI:18204) has functional parent progesterone (CHEBI:17026)
16α-hydroxyprogesterone (CHEBI:15826) has functional parent progesterone (CHEBI:17026)
16β-methylpregn-4-ene-3,20-dione (CHEBI:79767) has functional parent progesterone (CHEBI:17026)
17α-hydroxyprogesterone (CHEBI:17252) has functional parent progesterone (CHEBI:17026)
2,5-dioxo-1-pyrrolidinyl 6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoate (CHEBI:62026) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisol (CHEBI:78595) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisone (CHEBI:78596) has functional parent progesterone (CHEBI:17026)
3-(progesterone-4-yl)thiopropionic acid (CHEBI:62022) has functional parent progesterone (CHEBI:17026)
3-(progesterone-7α-yl)thiopropionic acid (CHEBI:62023) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β-ol-20-one (CHEBI:85899) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β,20α-diol (CHEBI:85903) has functional parent progesterone (CHEBI:17026)
5alpha,20alpha-tetrahydroprogesterone (CHEBI:233713) has functional parent progesterone (CHEBI:17026)
5α-pregnane-3,20-dione (CHEBI:28952) has functional parent progesterone (CHEBI:17026)
6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoic acid (CHEBI:62025) has functional parent progesterone (CHEBI:17026)
6-{3-[(progesterone-4-yl)thiopropionyl]amino}hexanoic acid (CHEBI:62024) has functional parent progesterone (CHEBI:17026)
6β,16α,17α-trihydroxyprogesterone (CHEBI:137046) has functional parent progesterone (CHEBI:17026)
9-fluoro-2α-methylpregn-4-ene-3,11,20-trione (CHEBI:79773) has functional parent progesterone (CHEBI:17026)
progesterone 3-O-(carboxymethyl)oxime (CHEBI:62042) has functional parent progesterone (CHEBI:17026)
Δ1-progesterone (CHEBI:34073) has functional parent progesterone (CHEBI:17026)
IUPAC Name 
pregn-4-ene-3,20-dione
INN  Source
progesteronaWHO MedNet
Synonyms  Source
17α-progesteroneNIST Chemistry WebBook
4-Pregnene-3,20-dioneKEGG COMPOUND
AgolutinNIST Chemistry WebBook
AkrolutinChEBI
corpus luteum hormoneChemIDplus
CrinoneChemIDplus
Brand Names  Source
EndometrinChEMBL
LutigestChEMBL
MilprosaChEMBL
Progesta-careChEMBL
Progesterone component of bijuvaChEMBL
RegumateChEMBL
UniProt Name  Source
progesteroneUniProt
Manual XrefsDatabases
2279DrugCentral
C00410KEGG COMPOUND
C00410KEGG COMPOUND
D00066KEGG DRUG
DB00396DrugBank
HMDB0001830HMDB
ProgesteroneWikipedia
PROGESTERONEMetaCyc
STRPDBeChem
Registry NumbersSources
Reaxys:1915950Reaxys
Gmelin:708590Gmelin
CAS:57-83-0NIST Chemistry WebBook
CAS:57-83-0KEGG COMPOUND
CAS:57-83-0ChemIDplus
Citations