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CHEBI:17026 - progesterone
| Formula | C21H30O2 |
| Net Charge | 0 |
| Average Mass | 314.469 |
| Monoisotopic Mass | 314.22458 |
| SMILES | [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H] |
| InChI | InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 |
| InChIKey | RJKFOVLPORLFTN-LEKSSAKUSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) | |
| Mus musculus (ncbitaxon:10090) | - | PubMed (19425150) | Source: BioModels - MODEL1507180067 |
| Roles Classification |
|---|
| Biological Roles: | progestin A synthetic progestogen. antiviral agent A substance that destroys or inhibits replication of viruses. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. progesterone receptor agonist A hormone agonist that binds to and activates progesterone receptors. mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. anticoagulant An agent that prevents blood clotting. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. progesterone receptor agonist A hormone agonist that binds to and activates progesterone receptors. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anticonvulsant A drug used to prevent seizures or reduce their severity. bone density conservation agent An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis. appetite enhancer A drug which increases appetite. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. contraceptive drug A chemical substance that prevents or reduces the probability of conception. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| progesterone (CHEBI:17026) has parent hydride pregnane (CHEBI:8386) |
| progesterone (CHEBI:17026) has role anti-HIV agent (CHEBI:64946) |
| progesterone (CHEBI:17026) has role anticoagulant (CHEBI:50249) |
| progesterone (CHEBI:17026) has role anticonvulsant (CHEBI:35623) |
| progesterone (CHEBI:17026) has role antidepressant (CHEBI:35469) |
| progesterone (CHEBI:17026) has role antihypertensive agent (CHEBI:35674) |
| progesterone (CHEBI:17026) has role antineoplastic agent (CHEBI:35610) |
| progesterone (CHEBI:17026) has role antiviral agent (CHEBI:22587) |
| progesterone (CHEBI:17026) has role appetite enhancer (CHEBI:50779) |
| progesterone (CHEBI:17026) has role bone density conservation agent (CHEBI:50646) |
| progesterone (CHEBI:17026) has role cardiovascular drug (CHEBI:35554) |
| progesterone (CHEBI:17026) has role contraceptive drug (CHEBI:49323) |
| progesterone (CHEBI:17026) has role human metabolite (CHEBI:77746) |
| progesterone (CHEBI:17026) has role hypoglycemic agent (CHEBI:35526) |
| progesterone (CHEBI:17026) has role mouse metabolite (CHEBI:75771) |
| progesterone (CHEBI:17026) has role neuroprotective agent (CHEBI:63726) |
| progesterone (CHEBI:17026) has role progesterone receptor agonist (CHEBI:70709) |
| progesterone (CHEBI:17026) has role progestin (CHEBI:59826) |
| progesterone (CHEBI:17026) is a 20-oxo steroid (CHEBI:36885) |
| progesterone (CHEBI:17026) is a 3-oxo-Δ4 steroid (CHEBI:47909) |
| progesterone (CHEBI:17026) is a C21-steroid hormone (CHEBI:64600) |
| Incoming Relation(s) |
| 11-deoxycorticosterone (CHEBI:16973) has functional parent progesterone (CHEBI:17026) |
| 11,21-dioxoprogesterone (CHEBI:78601) has functional parent progesterone (CHEBI:17026) |
| 11α-hydroxyprogesterone (CHEBI:16076) has functional parent progesterone (CHEBI:17026) |
| 11β-hydroxyprogesterone (CHEBI:28247) has functional parent progesterone (CHEBI:17026) |
| 12α-hydroxyprogesterone (CHEBI:34153) has functional parent progesterone (CHEBI:17026) |
| 15β-hydroxyprogesterone (CHEBI:59418) has functional parent progesterone (CHEBI:17026) |
| 16,17-didehydroprogesterone (CHEBI:18204) has functional parent progesterone (CHEBI:17026) |
| 16α-hydroxyprogesterone (CHEBI:15826) has functional parent progesterone (CHEBI:17026) |
| 16β-methylpregn-4-ene-3,20-dione (CHEBI:79767) has functional parent progesterone (CHEBI:17026) |
| 17α-hydroxyprogesterone (CHEBI:17252) has functional parent progesterone (CHEBI:17026) |
| 2,5-dioxo-1-pyrrolidinyl 6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoate (CHEBI:62026) has functional parent progesterone (CHEBI:17026) |
| 21-dehydrocortisol (CHEBI:78595) has functional parent progesterone (CHEBI:17026) |
| 21-dehydrocortisone (CHEBI:78596) has functional parent progesterone (CHEBI:17026) |
| 3-(progesterone-4-yl)thiopropionic acid (CHEBI:62022) has functional parent progesterone (CHEBI:17026) |
| 3-(progesterone-7α-yl)thiopropionic acid (CHEBI:62023) has functional parent progesterone (CHEBI:17026) |
| 4-pregnen-3β-ol-20-one (CHEBI:85899) has functional parent progesterone (CHEBI:17026) |
| 4-pregnen-3β,20α-diol (CHEBI:85903) has functional parent progesterone (CHEBI:17026) |
| 5alpha,20alpha-tetrahydroprogesterone (CHEBI:233713) has functional parent progesterone (CHEBI:17026) |
| 5α-pregnane-3,20-dione (CHEBI:28952) has functional parent progesterone (CHEBI:17026) |
| 6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoic acid (CHEBI:62025) has functional parent progesterone (CHEBI:17026) |
| 6-{3-[(progesterone-4-yl)thiopropionyl]amino}hexanoic acid (CHEBI:62024) has functional parent progesterone (CHEBI:17026) |
| 6β,16α,17α-trihydroxyprogesterone (CHEBI:137046) has functional parent progesterone (CHEBI:17026) |
| 9-fluoro-2α-methylpregn-4-ene-3,11,20-trione (CHEBI:79773) has functional parent progesterone (CHEBI:17026) |
| progesterone 3-O-(carboxymethyl)oxime (CHEBI:62042) has functional parent progesterone (CHEBI:17026) |
| Δ1-progesterone (CHEBI:34073) has functional parent progesterone (CHEBI:17026) |
| IUPAC Name |
|---|
| pregn-4-ene-3,20-dione |
| INN | Source |
|---|---|
| progesterona | WHO MedNet |
| Synonyms | Source |
|---|---|
| 17α-progesterone | NIST Chemistry WebBook |
| 4-Pregnene-3,20-dione | KEGG COMPOUND |
| Agolutin | NIST Chemistry WebBook |
| Akrolutin | ChEBI |
| corpus luteum hormone | ChemIDplus |
| Crinone | ChemIDplus |
| Brand Names | Source |
|---|---|
| Endometrin | ChEMBL |
| Lutigest | ChEMBL |
| Milprosa | ChEMBL |
| Progesta-care | ChEMBL |
| Progesterone component of bijuva | ChEMBL |
| Regumate | ChEMBL |
| UniProt Name | Source |
|---|---|
| progesterone | UniProt |
| Manual Xrefs | Databases |
|---|---|
| 2279 | DrugCentral |
| C00410 | KEGG COMPOUND |
| C00410 | KEGG COMPOUND |
| D00066 | KEGG DRUG |
| DB00396 | DrugBank |
| HMDB0001830 | HMDB |
| Progesterone | Wikipedia |
| PROGESTERONE | MetaCyc |
| STR | PDBeChem |
| Citations |
|---|