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CHEBI:27974 - estriol
| Formula | C18H24O3 |
| Net Charge | 0 |
| Average Mass | 288.387 |
| Monoisotopic Mass | 288.17254 |
| SMILES | [H][C@@]12CCc3cc(O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]21[H] |
| InChI | InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1 |
| InChIKey | PROQIPRRNZUXQM-ZXXIGWHRSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) | |
| Mus musculus (ncbitaxon:10090) | - | PubMed (19425150) | Source: BioModels - MODEL1507180067 |
| Roles Classification |
|---|
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. human xenobiotic metabolite Any human metabolite produced by metabolism of a xenobiotic compound in humans. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). estrogen A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens. |
| Application: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| estriol (CHEBI:27974) has parent hydride estrane (CHEBI:23966) |
| estriol (CHEBI:27974) has role estrogen (CHEBI:50114) |
| estriol (CHEBI:27974) has role human metabolite (CHEBI:77746) |
| estriol (CHEBI:27974) has role human xenobiotic metabolite (CHEBI:76967) |
| estriol (CHEBI:27974) has role immunosuppressive agent (CHEBI:35705) |
| estriol (CHEBI:27974) has role mouse metabolite (CHEBI:75771) |
| estriol (CHEBI:27974) is a 16α-hydroxy steroid (CHEBI:16799) |
| estriol (CHEBI:27974) is a 17β-hydroxy steroid (CHEBI:35343) |
| estriol (CHEBI:27974) is a 3-hydroxy steroid (CHEBI:36834) |
| Incoming Relation(s) |
| 3-(allyloxy)estra-1,3,5(10)-triene-16α,17β-diol (CHEBI:79756) has functional parent estriol (CHEBI:27974) |
| 6-ketoestriol (CHEBI:145763) has functional parent estriol (CHEBI:27974) |
| estriol 16-O-(β-D-glucuronide) (CHEBI:766) has functional parent estriol (CHEBI:27974) |
| estriol 3-O-(β-D-glucuronide) (CHEBI:45869) has functional parent estriol (CHEBI:27974) |
| IUPAC Name |
|---|
| estra-1,3,5(10)-triene-3,16α,17β-triol |
| INNs | Source |
|---|---|
| estriol succinate | WHO MedNet |
| succinate d'estriol | WHO MedNet |
| succinato de estriol | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol | KEGG COMPOUND |
| 16.alpha.,17.beta.-estriol | ChEMBL |
| 16.ALPHA.-HYDROXYESTRADIOL | ChEMBL |
| (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol | NIST Chemistry WebBook |
| 16α-hydroxyestradiol | NIST Chemistry WebBook |
| 3,16α,17β-trihydroxy-Δ1,3,5-estratriene | NIST Chemistry WebBook |
| Brand Names | Source |
|---|---|
| Deuslon-A | DrugBank |
| Estriel | DrugBank |
| Gynest | ChEMBL |
| UniProt Name | Source |
|---|---|
| 16α,17β-estriol | UniProt |
| Citations |
|---|