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CHEBI:27834 - pentostatin

ChEBI IDCHEBI:27834
ChEBI Namepentostatin
Stars
DefinitionA member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.
Secondary ChEBI IDsCHEBI:4406, CHEBI:23617, CHEBI:41829
Last Modified1 March 2024
DownloadsMolfile
Wikipedia
Species of MetaboliteComponentSourceComments
Aspergillus nidulans (ncbitaxon:162425) - DOI (10.1080/00021369.1979.10863817) Strain: Y 176-2
Roles Classification
Biological Roles:
antimetabolite  A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
bacterial metabolite  Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
Aspergillus metabolite  Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus .
EC 3.5.4.4 (adenosine deaminase) inhibitor  An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of adenosine deaminase (EC 3.5.4.4).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
pentostatin (CHEBI:27834) has role Aspergillus metabolite (CHEBI:76956)
pentostatin (CHEBI:27834) has role antimetabolite (CHEBI:35221)
pentostatin (CHEBI:27834) has role antineoplastic agent (CHEBI:35610)
pentostatin (CHEBI:27834) has role bacterial metabolite (CHEBI:76969)
pentostatin (CHEBI:27834) has role EC 3.5.4.4 (adenosine deaminase) inhibitor (CHEBI:50445)
pentostatin (CHEBI:27834) is a coformycins (CHEBI:39304)
pentostatin (CHEBI:27834) is conjugate base of pentostatin(1+) (CHEBI:229687)
Incoming Relation(s)
pentostatin(1+) (CHEBI:229687) is conjugate acid of pentostatin (CHEBI:27834)
IUPAC Name 
(8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
INNs  Source
pentostatinWHO MedNet
pentostatinumWHO MedNet
pentostatineWHO MedNet
pentostatinaWHO MedNet
Synonyms  Source
deoxycoformycinKEGG COMPOUND
CI825ChEBI
PD81565ChEBI
CI 825DrugBank
PD-ADIDrugBank
PD-81565DrugBank
Brand Name  Source
NipentDrugBank
Manual XrefsDatabases
C02267KEGG COMPOUND
D00155KEGG DRUG
2098DrugCentral
HMDB0014692HMDB
PentostatinWikipedia
DB00552DrugBank
DCFPDBeChem
US20040181052Patent
Registry NumbersSources
CAS:53910-25-1KEGG COMPOUND
Citations