EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:194100 - Ru360

ChEBI IDCHEBI:194100
ChEBI NameRu360
Stars
DefinitionA binuclear oxo-bridged Ru compound that selectively inhibits mitochondrial calcium uniporter mediated Ca2+-uptake with nanomolar potency in cells.
Last Modified23 December 2022
SubmitterTheOtherDave
DownloadsMolfile
FormulaC2H26N8O5Ru2.3Cl
Net Charge+5
Average Mass550.780
Monoisotopic Mass550.91513
SMILES[Cl-].[Cl-].[Cl-].[H]C(=O)[O][Ru]([NH3+])([NH3+])([NH3+])([NH3+])[O][Ru]([NH3+])([NH3+])([NH3+])([NH3+])[O]C([H])=O
InChIInChI=1S/2CH2O2.3ClH.8H3N.O.2Ru/c2*2-1-3;;;;;;;;;;;;;;/h2*1H,(H,2,3);3*1H;8*1H3;;;/q;;;;;;;;;;;;;;2*+5/p-5
InChIKeyGAQYLINTMDTWDS-UHFFFAOYSA-I
Wikipedia
Roles Classification
Biological Roles:
mitochondrial calcium uniporter inhibitor  Any inhibitor of mitochondrial calcium uniporter.
calcium channel blocker  One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application:
cardioprotective agent  Any protective agent that is able to prevent damage to the heart.
ChEBI Ontology
Outgoing Relation(s)
Ru360 (CHEBI:194100) has role calcium channel blocker (CHEBI:38215)
Ru360 (CHEBI:194100) has role cardioprotective agent (CHEBI:77307)
Ru360 (CHEBI:194100) has role mitochondrial calcium uniporter inhibitor (CHEBI:194181)
Ru360 (CHEBI:194100) is a ruthenium coordination entity (CHEBI:35733)
Synonyms  Source
Ru360ChEBI
ruthenium 360SUBMITTER
Ru-360ChEBI
Ru 360ChEBI
ruthenium-360ChEBI
Manual XrefsDatabases
Ru360Wikipedia
Registry NumbersSources
CAS:133399-54-9ChEBI
Citations