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CHEBI:192744 - lobaplatin
| ChEBI ID | CHEBI:192744 |
| ChEBI Name | lobaplatin |
| Stars | |
| Definition | A 1:1 diastereomeric mixture comprising of R,R,S and S,S,S configuration of platinum(II) complexes with 1,2-bis(aminomethyl)cyclobutane as the carrier ligand and lactate as the leaving group. It is a third-generation platinum anticancer drug approved in China for the treatment of chronic myelogenous leukaemia, inoperable metastatic breast cancer and small cell lung cancer. |
| Last Modified | 21 February 2023 |
| Submitter | slaulederkind |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. cross-linking reagent A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| lobaplatin (CHEBI:192744) has part (R,R,S)-lobaplatin (CHEBI:194425) |
| lobaplatin (CHEBI:192744) has part (S,S,S)-lobaplatin (CHEBI:194426) |
| lobaplatin (CHEBI:192744) has role antineoplastic agent (CHEBI:35610) |
| lobaplatin (CHEBI:192744) has role apoptosis inducer (CHEBI:68495) |
| lobaplatin (CHEBI:192744) has role cross-linking reagent (CHEBI:50684) |
| lobaplatin (CHEBI:192744) is a diastereoisomeric mixture (CHEBI:60915) |
| lobaplatin (CHEBI:192744) is a platinum coordination entity (CHEBI:33862) |
| INNs | Source |
|---|---|
| lobaplatine | WHO MedNet |
| lobaplatinum | WHO MedNet |
| lobaplatin | WHO MedNet |
| lobaplatino | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1,2-diamino-methylcyclobutane platinum(II) lactate | SUBMITTER |
| D-19466 | SUBMITTER |
| [2-hydroxypropanoato(2−)-O1,O2][1,2-cyclobutanedimethanamine-N,N']platinum(II) | ChEBI |
| 1,2-diamino-methylcyclobutane-platinum(II) lactate | ChEBI |
| D 19466 | ChEBI |
| D19466 | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| DB13049 | DrugBank |
| Lobaplatin | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| CAS:135558-11-1 | ChemIDplus |
| Citations |
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