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CHEBI:191209 - 7-methyl-guanosine-5'-triphosphate-5'-guanosine

ChEBI IDCHEBI:191209
ChEBI Name7-methyl-guanosine-5'-triphosphate-5'-guanosine
Stars
DefinitionA guanosine 5'-phosphate that is 7-methyl-GTP in which the hydroxy group of the terminal phosphate is substituted by a guanosinyl group. It is a cap analog that can be incorporated into mRNA.
Secondary ChEBI IDCHEBI:157761
Last Modified28 April 2022
SubmitterKalpana P, Sandra Orchard
DownloadsMolfile
FormulaC21H30N10O18P3
Net Charge+1
Average Mass803.445
Monoisotopic Mass803.09469
SMILESC[n+]1cn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c2nc(N)nc(=O)c21
InChIInChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p+1/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
InChIKeyFHHZHGZBHYYWTG-INFSMZHSSA-O
Roles Classification
Biological Role:
mouse metabolite  Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
ChEBI Ontology
Outgoing Relation(s)
7-methyl-guanosine-5'-triphosphate-5'-guanosine (CHEBI:191209) has functional parent 7-methyl-GTP (CHEBI:50210)
7-methyl-guanosine-5'-triphosphate-5'-guanosine (CHEBI:191209) is a guanosine 5'-phosphate (CHEBI:37121)
7-methyl-guanosine-5'-triphosphate-5'-guanosine (CHEBI:191209) is a purine ribonucleoside 5'-triphosphate (CHEBI:37045)
7-methyl-guanosine-5'-triphosphate-5'-guanosine (CHEBI:191209) is conjugate acid of (N7-methyl 5'-triphospho-guanosine)-guanosine(2−) (CHEBI:144024)
Incoming Relation(s)
(N7-methyl 5'-triphospho-guanosine)-guanosine(2−) (CHEBI:144024) is conjugate base of 7-methyl-guanosine-5'-triphosphate-5'-guanosine (CHEBI:191209)
IUPAC Name 
2-amino-9-[(2R,3R,4S,5R)-5-({[{[{[{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
Synonyms  Source
m7GpppGSUBMITTER
[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-7-ium-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphatePDBeChem
7-methyl-diguanosine triphosphateChemIDplus
mRNA cap analog N7-methyl GpppGDrugBank
7-methyl-GpppGChemIDplus
m7G(5')ppp(5')GChemIDplus
Manual XrefsDatabases
GTGPDBeChem
DB03958DrugBank
108799ChemSpider
WO2017066781Patent
Registry NumbersSources
CAS:62828-64-2ChemIDplus
Citations