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CHEBI:189866 - PPDA

ChEBI IDCHEBI:189866
ChEBI NamePPDA
Stars
DefinitionA racemate comprising equimolar amounts of (2R,3S)- and (2S,3R)-PPDA. It is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors.
Last Modified11 May 2022
Submitterslaulederkind
FormulaC21H18N2O5
Net Charge0
Average Mass378.384
Monoisotopic Mass378.12157
Roles Classification
Biological Role:
NMDA receptor antagonist  Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
ChEBI Ontology
Outgoing Relation(s)
PPDA (CHEBI:189866) has part (2R,3S)-PPDA (CHEBI:189871)
PPDA (CHEBI:189866) has part (2S,3R)-PPDA (CHEBI:189872)
PPDA (CHEBI:189866) has role NMDA receptor antagonist (CHEBI:60643)
PPDA (CHEBI:189866) is a racemate (CHEBI:60911)
IUPAC Name 
rac-(2R,3S)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid
Synonyms  Source
cis-PPDASUBMITTER
cis-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acidChEBI
(2S*,3R*)-1-(phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acidChEBI
Registry NumbersSources
CAS:684283-16-7ChEBI
Citations